Risk stratification study of assessing cervical Precancer by cytology, high risk human papillomavirus in Colposcopy examination

Objective To evaluate pooled risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) based on the various combinations of cytology, HR-HPV (high risk human papillomavirus), and colposcopy impression. Methods A total of 822 cases were selected from the colposcopy outpatient database of Shenzhen Maternity & Child Healthcare Hospital from January to December 2018. We assessed the risk of CIN2+ based on the combinations of three test results (cytology, HR-HPV, and colposcopy). Results If two of the test results were found highly abnormality (HSIL+, HPV16/18+ and high-grade colposcopic impression), the risks for CIN2+ was higher than 60%. If three highly abnormal test results were found, the risk for CIN2+ was 97.1%. Conclusio When at least two abnormal results in cytology HR-HPV and colposcopy are found, the CIN2+ risk was quite high. Attention should be paid to reduce unnecessary misdiagnosis and missed diagnosis.