TY - JOUR
T1 - Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis
T2 - A population-based cohort study
AU - On behalf of the PROMPT Study Group
AU - Charlton, Rachel
AU - Green, Amelia
AU - Shaddick, Gavin
AU - Snowball, Julia
AU - Nightingale, Alison
AU - Tillett, William
AU - Smith, Catherine H.
AU - McHugh, Neil
AU - Hewlett, Sarah
AU - Harris, Helen
AU - Helliwell, Philip
AU - Coates, Laura
AU - Fernandez, Catherine
AU - Brown, Sarah
AU - Davies, Claire
AU - Packham, Jonathan
AU - Bjoke, Laura
AU - Spakman, Eldon
AU - Barton, Anne
AU - Fitzgerald, Oliver
AU - Madhok, Vishnu
AU - Brooke, Melanie
AU - James, Jana
AU - Parkinson, Andrew
N1 - Publisher Copyright:
© 2018 Article author(s).
PY - 2018/2
Y1 - 2018/2
N2 - Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RRadj 3.55, 95% CI 2.21 to 5.70 and RRadj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RRadj 2.96, 95% CI 1.46 to 6.00 and RRadj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RRadj1.30, 95% CI 0.66 to 2.56 and RRadj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.
AB - Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were calculated using conditional Poisson regression. Results: 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RRadj 3.55, 95% CI 2.21 to 5.70 and RRadj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RRadj 2.96, 95% CI 1.46 to 6.00 and RRadj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RRadj1.30, 95% CI 0.66 to 2.56 and RRadj0.98, 95% CI 0.50 to 1.92). Conclusions: I n a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.
UR - http://www.scopus.com/inward/record.url?scp=85041552823&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2017-212328
DO - 10.1136/annrheumdis-2017-212328
M3 - Article
C2 - 29092855
AN - SCOPUS:85041552823
SN - 0003-4967
VL - 77
SP - 277
EP - 280
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 2
ER -