In November, 1999, all children under age 18 years in the UK were offered immunisation with the newly introduced meningococcal C conjugate vaccine (MCCV). In a cohort of 106 patients with nephrotic syndrome, there were 63 relapses during the 12 months before vaccination, and 96 during the equivalent period postvaccination (p=0.009). The relapse rate of nephrotic syndrome increased significantly after administration of MCCV. Whether to vaccinate such children needs to be carefully considered.
Bibliographical noteFunding Information:
ASA was supported by The Caring for Kids Fund (Child Health Research Appeal Trust). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or in writing of the report.