TY - JOUR
T1 - Risk of lung cancer mortality in relation to lung doses among french uranium miners
T2 - Follow-up 19561999
AU - Rage, Estelle
AU - Vacquier, Blandine
AU - Blanchardon, Eric
AU - Allodji, Rodrigue S.
AU - Marsh, James
AU - Car-Lorho, Sylvaine
AU - Acker, Alain
AU - Laurier, Dominique
PY - 2012/3
Y1 - 2012/3
N2 - The aim of this study was to assess the risk of lung cancer death associated with cumulative lung doses from exposure to α-particle emitters, including radon gas, radon short-lived progeny, and long-lived radionuclides, and to external γ rays among French uranium miners. The French "post-55" sub-cohort included 3,377 uranium miners hired from 1956, followed up through the end of 1999, and contributing to 89,405 person-years. Lung doses were calculated with the ICRP Human Respiratory Tract Model (Publication 66) for 3,271 exposed miners. The mean "absorbed lung dose" due to α-particle radiation was 78 mGy, and that due to the contribution from other types of radiation (γ and β-particle radiation) was 56 mGy. Radon short-lived progeny accounted for 97 of the α-particle absorbed dose. Out of the 627 deaths, the cause of death was identified for 97.4, and 66 cases were due to lung cancer. A significant excess relative risk (ERR) of lung cancer death was associated with the total absorbed lung dose (ERR/Gy 2.94, 95 CI 0.80, 7.53) and the α-particle absorbed dose (4.48, 95 CI 1.27, 10.89). Assuming a value of 20 for the relative biological effectiveness (RBE) of α particles for lung cancer induction, the ERR/Gy-Eq for the total weighted lung dose was 0.22 (95 CI: 0.06, 0.53).
AB - The aim of this study was to assess the risk of lung cancer death associated with cumulative lung doses from exposure to α-particle emitters, including radon gas, radon short-lived progeny, and long-lived radionuclides, and to external γ rays among French uranium miners. The French "post-55" sub-cohort included 3,377 uranium miners hired from 1956, followed up through the end of 1999, and contributing to 89,405 person-years. Lung doses were calculated with the ICRP Human Respiratory Tract Model (Publication 66) for 3,271 exposed miners. The mean "absorbed lung dose" due to α-particle radiation was 78 mGy, and that due to the contribution from other types of radiation (γ and β-particle radiation) was 56 mGy. Radon short-lived progeny accounted for 97 of the α-particle absorbed dose. Out of the 627 deaths, the cause of death was identified for 97.4, and 66 cases were due to lung cancer. A significant excess relative risk (ERR) of lung cancer death was associated with the total absorbed lung dose (ERR/Gy 2.94, 95 CI 0.80, 7.53) and the α-particle absorbed dose (4.48, 95 CI 1.27, 10.89). Assuming a value of 20 for the relative biological effectiveness (RBE) of α particles for lung cancer induction, the ERR/Gy-Eq for the total weighted lung dose was 0.22 (95 CI: 0.06, 0.53).
UR - http://www.scopus.com/inward/record.url?scp=84859936699&partnerID=8YFLogxK
U2 - 10.1667/RR2689.1
DO - 10.1667/RR2689.1
M3 - Article
C2 - 22206233
AN - SCOPUS:84859936699
SN - 0033-7587
VL - 177
SP - 288
EP - 297
JO - Radiation Research
JF - Radiation Research
IS - 3
ER -
