Risk of lung cancer from radon exposure: Contribution of recently published studies of uranium miners

M. Tirmarche; John Harrison; D. Laurier; E. Blanchardon; F. Paquet; James Marsh

doi:10.1016/j.icrp.2012.06.033

Risk of lung cancer from radon exposure: Contribution of recently published studies of uranium miners

M. Tirmarche^*, John Harrison, D. Laurier, E. Blanchardon, F. Paquet, James Marsh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The International Commission on Radiological Protection (ICRP) recently estimated the risk of lung cancer associated with radon exposure, and a statement was issued in ICRP Publication 115. This was based on recent epidemiological studies and the results from a joint analysis of cohorts of Czech, French, and German uranium miners, and indicated that the excess relative risk of lung cancer per unit of exposure should be expressed with consideration of chronic exposure over more than 10. years, by modelling time since median exposure, age attained or age at exposure, and taking in account, if possible, interaction between radon and tobacco.The lifetime excess absolute risk (LEAR) calculated from occupational exposure studies is close to 5×10^-4 per working level month (WLM) (14×10^-5 per hmJ/m³). LEAR values estimated using risk models derived from both miners and domestic exposure studies are in good agreement after accounting for factors such as sex, attained age, and exposure scenario. A sensitivity analysis highlighted the high dependence of background mortality rates on LEAR estimates. Using lung cancer rates among Euro-American males instead of the ICRP reference rates (males and females, and Euro-American and Asian populations), the estimated LEAR is close to 7×10^-4 per WLM (20×10^-5 per hm J/m³).

Original language	English
Pages (from-to)	368-377
Number of pages	10
Journal	Annals of the ICRP
Volume	41
Issue number	3-4
DOIs	https://doi.org/10.1016/j.icrp.2012.06.033
Publication status	Published - Oct 2012

Bibliographical note

Funding Information:
Tirmarche, M., Laurier, D., Bochicchio, F., et al., 2009. Final scientific report of the Alpha Risk Project funded by the European Commission EC FP6 (ref. FI6R-CT-2005-516483), Brussels, Belgium: European Commission . Available from: http://www.irsn.fr .

Keywords

Epidemiology
Excess absolute risk
ICRP
Lung cancer
Radon exposure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.icrp.2012.06.033

Cite this

@article{8e72f6ed9a4947be9aa09064b179adbc,

title = "Risk of lung cancer from radon exposure: Contribution of recently published studies of uranium miners",

abstract = "The International Commission on Radiological Protection (ICRP) recently estimated the risk of lung cancer associated with radon exposure, and a statement was issued in ICRP Publication 115. This was based on recent epidemiological studies and the results from a joint analysis of cohorts of Czech, French, and German uranium miners, and indicated that the excess relative risk of lung cancer per unit of exposure should be expressed with consideration of chronic exposure over more than 10. years, by modelling time since median exposure, age attained or age at exposure, and taking in account, if possible, interaction between radon and tobacco.The lifetime excess absolute risk (LEAR) calculated from occupational exposure studies is close to 5×10-4 per working level month (WLM) (14×10-5 per hmJ/m3). LEAR values estimated using risk models derived from both miners and domestic exposure studies are in good agreement after accounting for factors such as sex, attained age, and exposure scenario. A sensitivity analysis highlighted the high dependence of background mortality rates on LEAR estimates. Using lung cancer rates among Euro-American males instead of the ICRP reference rates (males and females, and Euro-American and Asian populations), the estimated LEAR is close to 7×10-4 per WLM (20×10-5 per hm J/m3).",

keywords = "Epidemiology, Excess absolute risk, ICRP, Lung cancer, Radon exposure",

author = "M. Tirmarche and John Harrison and D. Laurier and E. Blanchardon and F. Paquet and James Marsh",

note = "Funding Information: Tirmarche, M., Laurier, D., Bochicchio, F., et al., 2009. Final scientific report of the Alpha Risk Project funded by the European Commission EC FP6 (ref. FI6R-CT-2005-516483), Brussels, Belgium: European Commission . Available from: http://www.irsn.fr . ",

year = "2012",

month = oct,

doi = "10.1016/j.icrp.2012.06.033",

language = "English",

volume = "41",

pages = "368--377",

journal = "Annals of the ICRP",

issn = "0146-6453",

publisher = "SAGE Publications",

number = "3-4",

}

TY - JOUR

T1 - Risk of lung cancer from radon exposure

T2 - Contribution of recently published studies of uranium miners

AU - Tirmarche, M.

AU - Harrison, John

AU - Laurier, D.

AU - Blanchardon, E.

AU - Paquet, F.

AU - Marsh, James

N1 - Funding Information: Tirmarche, M., Laurier, D., Bochicchio, F., et al., 2009. Final scientific report of the Alpha Risk Project funded by the European Commission EC FP6 (ref. FI6R-CT-2005-516483), Brussels, Belgium: European Commission . Available from: http://www.irsn.fr .

PY - 2012/10

Y1 - 2012/10

N2 - The International Commission on Radiological Protection (ICRP) recently estimated the risk of lung cancer associated with radon exposure, and a statement was issued in ICRP Publication 115. This was based on recent epidemiological studies and the results from a joint analysis of cohorts of Czech, French, and German uranium miners, and indicated that the excess relative risk of lung cancer per unit of exposure should be expressed with consideration of chronic exposure over more than 10. years, by modelling time since median exposure, age attained or age at exposure, and taking in account, if possible, interaction between radon and tobacco.The lifetime excess absolute risk (LEAR) calculated from occupational exposure studies is close to 5×10-4 per working level month (WLM) (14×10-5 per hmJ/m3). LEAR values estimated using risk models derived from both miners and domestic exposure studies are in good agreement after accounting for factors such as sex, attained age, and exposure scenario. A sensitivity analysis highlighted the high dependence of background mortality rates on LEAR estimates. Using lung cancer rates among Euro-American males instead of the ICRP reference rates (males and females, and Euro-American and Asian populations), the estimated LEAR is close to 7×10-4 per WLM (20×10-5 per hm J/m3).

AB - The International Commission on Radiological Protection (ICRP) recently estimated the risk of lung cancer associated with radon exposure, and a statement was issued in ICRP Publication 115. This was based on recent epidemiological studies and the results from a joint analysis of cohorts of Czech, French, and German uranium miners, and indicated that the excess relative risk of lung cancer per unit of exposure should be expressed with consideration of chronic exposure over more than 10. years, by modelling time since median exposure, age attained or age at exposure, and taking in account, if possible, interaction between radon and tobacco.The lifetime excess absolute risk (LEAR) calculated from occupational exposure studies is close to 5×10-4 per working level month (WLM) (14×10-5 per hmJ/m3). LEAR values estimated using risk models derived from both miners and domestic exposure studies are in good agreement after accounting for factors such as sex, attained age, and exposure scenario. A sensitivity analysis highlighted the high dependence of background mortality rates on LEAR estimates. Using lung cancer rates among Euro-American males instead of the ICRP reference rates (males and females, and Euro-American and Asian populations), the estimated LEAR is close to 7×10-4 per WLM (20×10-5 per hm J/m3).

KW - Epidemiology

KW - Excess absolute risk

KW - ICRP

KW - Lung cancer

KW - Radon exposure

UR - http://www.scopus.com/inward/record.url?scp=84867756884&partnerID=8YFLogxK

U2 - 10.1016/j.icrp.2012.06.033

DO - 10.1016/j.icrp.2012.06.033

M3 - Article

C2 - 23089036

AN - SCOPUS:84867756884

SN - 0146-6453

VL - 41

SP - 368

EP - 377

JO - Annals of the ICRP

JF - Annals of the ICRP

IS - 3-4

ER -

Risk of lung cancer from radon exposure: Contribution of recently published studies of uranium miners

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this