Rifampicin-resistant Mycobacterium tuberculosis: Susceptibility to isoniazid and other anti-tuberculosis drugs

Ekaterina V. Kurbatova; J. S. Cavanaugh; N. S. Shah; A. Wright; H. Kim; B. Metchock; A. Van Deun; L. Barrera; F. Boulahbal; E. Richter; N. Martín-Casabona; F. Arias; I. Zemanova; F. Drobniewski; A. Santos Silva; C. Coulter; R. Lumb; J. P. Cegielski

doi:10.5588/ijtld.11.0542

Rifampicin-resistant Mycobacterium tuberculosis: Susceptibility to isoniazid and other anti-tuberculosis drugs

Ekaterina V. Kurbatova^*, J. S. Cavanaugh, N. S. Shah, A. Wright, H. Kim, B. Metchock, A. Van Deun, L. Barrera, F. Boulahbal, E. Richter, N. Martín-Casabona, F. Arias, I. Zemanova, F. Drobniewski, A. Santos Silva, C. Coulter, R. Lumb, J. P. Cegielski

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Based on data from 14 Supranational Tuberculosis (TB) Reference Laboratories worldwide, the proportion of rifampicin (RMP) resistant isolates that were isoniazid (INH) susceptible by phenotypic drug susceptibility testing varied widely (0.5-11.6%). RMP-resistant isolates that were INH-susceptible had significantly lower rates of resistance to other first- and second-line anti-tuberculosis drugs (except rifabutin) compared to multidrug-resistant isolates. RMP resistance is not a lways a good proxy for a presumptive diagnosis of multidrug-resistant TB, which has implications for use of molecular assays that identify only RMP resistanceassociated DNA mutations.

Original language	English
Pages (from-to)	355-357
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	16
Issue number	3
DOIs	https://doi.org/10.5588/ijtld.11.0542
Publication status	Published - 1 Mar 2012

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

Drug resistance
Molecular diagnostic tests
Rifampicin resistance
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.11.0542

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Kurbatova, E. V., Cavanaugh, J. S., Shah, N. S., Wright, A., Kim, H., Metchock, B., Van Deun, A., Barrera, L., Boulahbal, F., Richter, E., Martín-Casabona, N., Arias, F., Zemanova, I., Drobniewski, F., Santos Silva, A., Coulter, C., Lumb, R., & Cegielski, J. P. (2012). Rifampicin-resistant Mycobacterium tuberculosis: Susceptibility to isoniazid and other anti-tuberculosis drugs. International Journal of Tuberculosis and Lung Disease, 16(3), 355-357. https://doi.org/10.5588/ijtld.11.0542

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abstract = "Based on data from 14 Supranational Tuberculosis (TB) Reference Laboratories worldwide, the proportion of rifampicin (RMP) resistant isolates that were isoniazid (INH) susceptible by phenotypic drug susceptibility testing varied widely (0.5-11.6%). RMP-resistant isolates that were INH-susceptible had significantly lower rates of resistance to other first- and second-line anti-tuberculosis drugs (except rifabutin) compared to multidrug-resistant isolates. RMP resistance is not a lways a good proxy for a presumptive diagnosis of multidrug-resistant TB, which has implications for use of molecular assays that identify only RMP resistanceassociated DNA mutations.",

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Kurbatova, EV, Cavanaugh, JS, Shah, NS, Wright, A, Kim, H, Metchock, B, Van Deun, A, Barrera, L, Boulahbal, F, Richter, E, Martín-Casabona, N, Arias, F, Zemanova, I, Drobniewski, F, Santos Silva, A, Coulter, C, Lumb, R & Cegielski, JP 2012, 'Rifampicin-resistant Mycobacterium tuberculosis: Susceptibility to isoniazid and other anti-tuberculosis drugs', International Journal of Tuberculosis and Lung Disease, vol. 16, no. 3, pp. 355-357. https://doi.org/10.5588/ijtld.11.0542

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AU - Kurbatova, Ekaterina V.

AU - Cavanaugh, J. S.

AU - Shah, N. S.

AU - Wright, A.

AU - Kim, H.

AU - Metchock, B.

AU - Van Deun, A.

AU - Barrera, L.

AU - Boulahbal, F.

AU - Richter, E.

AU - Martín-Casabona, N.

AU - Arias, F.

AU - Zemanova, I.

AU - Drobniewski, F.

AU - Santos Silva, A.

AU - Coulter, C.

AU - Lumb, R.

AU - Cegielski, J. P.

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Rifampicin-resistant Mycobacterium tuberculosis: Susceptibility to isoniazid and other anti-tuberculosis drugs

Abstract

Bibliographical note

Keywords

UN SDGs

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