Review of translocations detected by fish for retrospective biological dosimetry applications

Alan Edwards*, C. Lindholm, F. Darroudi, G. Stephan, H. Romm, J. Barquinero, L. Barrios, M. R. Caballin, L. Roy, C. A. Whitehouse, E. J. Tawn, Jayne Moquet, D. C. Lloyd, P. Voisin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)

Abstract

Several European laboratories have combined their research efforts to arrive at a consensus view on using fluorescence in situ hybridisation (FISH) for retrospective dosimetry. The aim of this review is to report these views and to highlight some areas where further work is needed. Translocations in the stable cells should be measured only in the cells that contain the full complement of the painted material. Two-way and one-way translocations should be combined with equal weight. The control level of translocations has a strong dependence on age, which has now been measured and the system has been calibrated. In conclusion, the technique works and a lifetime dose to the bone marrow from low-linear energy transfer radiation of 0.5 Gy above normal background levels can be measured for any individual. The main application is considered to provide an independent verification of lifetime doses to individuals who might form a part of an epidemiological study.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalRadiation Protection Dosimetry
Volume113
Issue number4
DOIs
Publication statusPublished - 2005

Bibliographical note

Funding Information:
The authors would like to acknowledge the financial assistance of a CEC Concerted Action (FIGD-CT-200-20040) to fund meetings to allow the many pieces of information to be discussed, analysed and judged.

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