Retrospective estimation of Plutonium-239 doses from transfer to the fetus for Mayak PA workers

Vadim V. Vostrotin; Timothy Fell; Tracy J. Smith; Sergey Romanov

doi:10.3109/09553002.2014.909075

Retrospective estimation of Plutonium-239 doses from transfer to the fetus for Mayak PA workers

Vadim V. Vostrotin^*, Timothy Fell, Tracy J. Smith, Sergey Romanov

^*Corresponding author for this work

Radiation Hazards & Emergencies

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Purpose: The estimation of plutonium fetal transfer and the calculation of individual in utero and postnatal doses for the Mayak Production Association (PA) offspring cohort. Materials and methods: The model developed by the International Commission on Radiological Protection (ICRP) for the transfer of plutonium to the fetus following maternal intakes before and during pregnancy has been adjusted for application to analysis of the fetal transfer of ²³⁹Pu for Mayak workers. Improved estimates of fetal to maternal concentration ratios (CF:CM) have been obtained based on a correlation observed between adult offsprings' measured daily urine ²³⁹Pu activity and estimates of their mothers' systemic activity at conception. Data on ²³⁹Pu activity in daily urine samples were collected from 13 selected adults whose mothers worked at the Mayak PA facility during the period from 1948-1953, before and/or during pregnancy. Results: A comparison of measured and modeled excretion data enabled a mean value of 0.18 ± 0.02 (n = 21) to be inferred for the Pu CF:CM ratio, with a coefficient of variation of 60%. Conclusions: Point estimates of the individual in utero and postnatal absorbed doses for the red bone marrow and liver were in the range 2...13 mGy in 95% of the cases for the cohort of 1936 offspring.

Original language	English
Pages (from-to)	1036-1042
Number of pages	7
Journal	International Journal of Radiation Biology
Volume	90
Issue number	11
DOIs	https://doi.org/10.3109/09553002.2014.909075
Publication status	Published - 1 Nov 2014

Bibliographical note

Funding Information:
The study was carried out in the framework of the Work Package 4.3 of the International Project SOLO (Grant 249675) funded by the European Commission and the Federal Medical-Biological Agency (FMBA) of the Russian Federation. The authors would like to express gratitude to Klara Suslova (SUBI) and Tatyana Zulaeva (SUBI) for organizing the collection of daily urine from 13 offspring.

Publisher Copyright:
© 2014 Informa UK, Ltd.

Keywords

Internal dosimetry
Mayak PA
Plutonium
Postnatal
in utero

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title = "Retrospective estimation of Plutonium-239 doses from transfer to the fetus for Mayak PA workers",

abstract = "Purpose: The estimation of plutonium fetal transfer and the calculation of individual in utero and postnatal doses for the Mayak Production Association (PA) offspring cohort. Materials and methods: The model developed by the International Commission on Radiological Protection (ICRP) for the transfer of plutonium to the fetus following maternal intakes before and during pregnancy has been adjusted for application to analysis of the fetal transfer of 239Pu for Mayak workers. Improved estimates of fetal to maternal concentration ratios (CF:CM) have been obtained based on a correlation observed between adult offsprings' measured daily urine 239Pu activity and estimates of their mothers' systemic activity at conception. Data on 239Pu activity in daily urine samples were collected from 13 selected adults whose mothers worked at the Mayak PA facility during the period from 1948-1953, before and/or during pregnancy. Results: A comparison of measured and modeled excretion data enabled a mean value of 0.18 ± 0.02 (n = 21) to be inferred for the Pu CF:CM ratio, with a coefficient of variation of 60%. Conclusions: Point estimates of the individual in utero and postnatal absorbed doses for the red bone marrow and liver were in the range 2...13 mGy in 95% of the cases for the cohort of 1936 offspring.",

keywords = "Internal dosimetry, Mayak PA, Plutonium, Postnatal, in utero",

author = "Vostrotin, {Vadim V.} and Timothy Fell and Smith, {Tracy J.} and Sergey Romanov",

note = "Funding Information: The study was carried out in the framework of the Work Package 4.3 of the International Project SOLO (Grant 249675) funded by the European Commission and the Federal Medical-Biological Agency (FMBA) of the Russian Federation. The authors would like to express gratitude to Klara Suslova (SUBI) and Tatyana Zulaeva (SUBI) for organizing the collection of daily urine from 13 offspring. Publisher Copyright: {\textcopyright} 2014 Informa UK, Ltd.",

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doi = "10.3109/09553002.2014.909075",

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AU - Vostrotin, Vadim V.

AU - Fell, Timothy

AU - Smith, Tracy J.

AU - Romanov, Sergey

N1 - Funding Information: The study was carried out in the framework of the Work Package 4.3 of the International Project SOLO (Grant 249675) funded by the European Commission and the Federal Medical-Biological Agency (FMBA) of the Russian Federation. The authors would like to express gratitude to Klara Suslova (SUBI) and Tatyana Zulaeva (SUBI) for organizing the collection of daily urine from 13 offspring. Publisher Copyright: © 2014 Informa UK, Ltd.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Purpose: The estimation of plutonium fetal transfer and the calculation of individual in utero and postnatal doses for the Mayak Production Association (PA) offspring cohort. Materials and methods: The model developed by the International Commission on Radiological Protection (ICRP) for the transfer of plutonium to the fetus following maternal intakes before and during pregnancy has been adjusted for application to analysis of the fetal transfer of 239Pu for Mayak workers. Improved estimates of fetal to maternal concentration ratios (CF:CM) have been obtained based on a correlation observed between adult offsprings' measured daily urine 239Pu activity and estimates of their mothers' systemic activity at conception. Data on 239Pu activity in daily urine samples were collected from 13 selected adults whose mothers worked at the Mayak PA facility during the period from 1948-1953, before and/or during pregnancy. Results: A comparison of measured and modeled excretion data enabled a mean value of 0.18 ± 0.02 (n = 21) to be inferred for the Pu CF:CM ratio, with a coefficient of variation of 60%. Conclusions: Point estimates of the individual in utero and postnatal absorbed doses for the red bone marrow and liver were in the range 2...13 mGy in 95% of the cases for the cohort of 1936 offspring.

AB - Purpose: The estimation of plutonium fetal transfer and the calculation of individual in utero and postnatal doses for the Mayak Production Association (PA) offspring cohort. Materials and methods: The model developed by the International Commission on Radiological Protection (ICRP) for the transfer of plutonium to the fetus following maternal intakes before and during pregnancy has been adjusted for application to analysis of the fetal transfer of 239Pu for Mayak workers. Improved estimates of fetal to maternal concentration ratios (CF:CM) have been obtained based on a correlation observed between adult offsprings' measured daily urine 239Pu activity and estimates of their mothers' systemic activity at conception. Data on 239Pu activity in daily urine samples were collected from 13 selected adults whose mothers worked at the Mayak PA facility during the period from 1948-1953, before and/or during pregnancy. Results: A comparison of measured and modeled excretion data enabled a mean value of 0.18 ± 0.02 (n = 21) to be inferred for the Pu CF:CM ratio, with a coefficient of variation of 60%. Conclusions: Point estimates of the individual in utero and postnatal absorbed doses for the red bone marrow and liver were in the range 2...13 mGy in 95% of the cases for the cohort of 1936 offspring.

KW - Internal dosimetry

KW - Mayak PA

KW - Plutonium

KW - Postnatal

KW - in utero

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IS - 11

ER -

Retrospective estimation of Plutonium-239 doses from transfer to the fetus for Mayak PA workers

Abstract

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Keywords

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