Retrospective biodosimetry of an occupational overexposure-case study

L. A. Beaton-Green*, T. Barr, Elizabeth Ainsbury, R. C. Wilkins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

In 2014, Health Canada was approached by the Canadian Nuclear Safety Commission to conduct biodosimetry for a possible overexposure 4 y prior to assessment. Dose estimates were determined by means of two cytogenetic assays, the dicentric chromosome assay (DCA) and translocations as measured by the fluorescent in situ hybridization (FISH). As dicentrics are considered to be unstable over time, the results of the DCA were adjusted to account for the time elapsed between the suspected exposure and sampling. The frequency of damage was then compared to Health Canada's calibration curves, respectively, to calculate dose. In addition, the translocation data were corrected for age-related increases in background. With a half-life of 36 months for dicentric chromosomes taken into consideration, the dose estimates from both assays were in agreement. Due to the uncertainty in the half-life of dicentrics, the FISH assay is considered to be more reliable as a technique for retrospective biodosimetry.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalRadiation Protection Dosimetry
Volume172
Issue number1-3
DOIs
Publication statusPublished - Dec 2016

Bibliographical note

Publisher Copyright:
© The Author 2016.

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