Resolving the molecular mechanisms of radiation tumorigenesis: Past problems and future prospects

Major goals in experimental radiobiology continue to be the resolution of the fundamental mechanisms of cellular radiation response and to gain detailed understanding of the contribution made by these responses to the complex in vivo processes of tumor development. The coupling of this framework of fundamental knowledge to epidemiological measures of risk greatly strengthens the biological basis of radiological protection. A selective overview is provided of recent advances in the understanding of the mechanisms and genetics of radiation tumorigenesis and their possible implications. It is suggested that rapid technical and academic advances in biology greatly expand the opportunities to further refine scientific knowledge on tumor risk after radiation.