Resistance to carbapenems and other antibiotics in Klebsiella pneumoniae found in seals indicates anthropogenic pollution

James Paul Duff*, Manal Abuoun, Steve Bexton, Jon Rogers, Jane Turton, Neil Woodford, Richard Irvine, Muna Anjum, Christopher Teale

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background The beta-lactamase enzyme OXA-48 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L/M plasmids. OXA-48 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals. Furthermore, the use of carbapenem compounds is not permitted in food-producing animals in Europe and to our knowledge has not been reported in food-producing animals globally. Methods Bacterial isolates from lesions in stranded, free-living, juvenile common seals (Phoca vitulina) were identified. Antimicrobial susceptibility testing and whole genome sequencing analysis were used to characterise antimicrobial resistance genes carried by the bacteria. Results Here, we report the detection of Klebsiella pneumoniae subspecies pneumoniae carrying the bla OXA-48 gene on an incompatibility group L/M plasmid from an infection in a common seal. Conclusion Evidence is accruing that marine mammals may be infected with bacteria originating from anthropogenic sources, such as human sewage, contaminating the environment.

Original languageEnglish
Pages (from-to)154
Number of pages1
JournalVeterinary Record
Volume187
Issue number4
DOIs
Publication statusPublished - 22 Aug 2020

Bibliographical note

Funding Information:
Funding This work was funded by the Veterinary Medicines Directorate under VMD grant number VM0533. The APHA Diseases of Wildlife Scheme is funded by the Department for Environment, Food and Rural Affairs (Defra), project ED1600.

Publisher Copyright:
©

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • antimicrobials
  • bacteriology
  • marine mammals
  • molecular biology
  • resistance

Fingerprint

Dive into the research topics of 'Resistance to carbapenems and other antibiotics in Klebsiella pneumoniae found in seals indicates anthropogenic pollution'. Together they form a unique fingerprint.

Cite this