Residential greenness-related DNA methylation changes

Ayoung Jeong; Ikenna C. Eze; Danielle Vienneau; Kees de Hoogh; Dirk Keidel; Thomas Rothe; Luc Burdet; John W. Holloway; Debbie Jarvis; Florian Kronenberg; Gianfranco Lovison; Medea Imboden; Nicole Probst-Hensch

doi:10.1016/j.envint.2021.106945

Residential greenness-related DNA methylation changes

Ayoung Jeong^*, Ikenna C. Eze, Danielle Vienneau, Kees de Hoogh, Dirk Keidel, Thomas Rothe, Luc Burdet, John W. Holloway, Debbie Jarvis, Florian Kronenberg, Gianfranco Lovison, Medea Imboden, Nicole Probst-Hensch

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

Original language	English
Article number	106945
Journal	Environment International
Volume	158
DOIs	https://doi.org/10.1016/j.envint.2021.106945
Publication status	Published - Jan 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

Allergy
Allostatic load
DNA methylation
EWAS
Enrichment test
Greenness
Pathway analysis
Physical activity

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10.1016/j.envint.2021.106945

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title = "Residential greenness-related DNA methylation changes",

abstract = "Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.",

keywords = "Allergy, Allostatic load, DNA methylation, EWAS, Enrichment test, Greenness, Pathway analysis, Physical activity",

author = "Ayoung Jeong and Eze, {Ikenna C.} and Danielle Vienneau and {de Hoogh}, Kees and Dirk Keidel and Thomas Rothe and Luc Burdet and Holloway, {John W.} and Debbie Jarvis and Florian Kronenberg and Gianfranco Lovison and Medea Imboden and Nicole Probst-Hensch",

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year = "2022",

month = jan,

doi = "10.1016/j.envint.2021.106945",

language = "English",

volume = "158",

journal = "Environment International",

issn = "0160-4120",

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T1 - Residential greenness-related DNA methylation changes

AU - Jeong, Ayoung

AU - Eze, Ikenna C.

AU - Vienneau, Danielle

AU - de Hoogh, Kees

AU - Keidel, Dirk

AU - Rothe, Thomas

AU - Burdet, Luc

AU - Holloway, John W.

AU - Jarvis, Debbie

AU - Kronenberg, Florian

AU - Lovison, Gianfranco

AU - Imboden, Medea

AU - Probst-Hensch, Nicole

PY - 2022/1

Y1 - 2022/1

N2 - Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

AB - Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

KW - Allergy

KW - Allostatic load

KW - DNA methylation

KW - EWAS

KW - Enrichment test

KW - Greenness

KW - Pathway analysis

KW - Physical activity

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DO - 10.1016/j.envint.2021.106945

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AN - SCOPUS:85117619873

SN - 0160-4120

VL - 158

JO - Environment International

JF - Environment International

M1 - 106945

ER -

Residential greenness-related DNA methylation changes

Abstract

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Keywords

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