Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

Robert Jordan*, Stephanie L. Ford-Scheimer, Rodolfo M. Alarcon, Anthony Atala, Jeffrey T. Borenstein, Kyle R. Brimacombe, Sara Cherry, Hans Clevers, Mindy I. Davis, Simon G.P. Funnell, Lee Gehrke, Linda G. Griffith, Abigail C. Grossman, Thomas Hartung, Donald E. Ingber, Nicole C. Kleinstreuer, Calvin J. Kuo, Emily M. Lee, Christine L. Mummery, Thames E. PickettSasirekha Ramani, Edwin A. Rosado-Olivieri, Evi B. Struble, Zhengpeng Wan, Mark S. Williams, Matthew D. Hall, Marc Ferrer, Sarine Markossian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral drug development, practical advice, best practices, and case studies about the application of available 3D tissue models to infectious disease modeling. This report includes a summary of each workshop session as well as a discussion of perspectives and challenges related to the use of 3D tissues in antiviral drug discovery.

Original languageEnglish
Pages (from-to)S337-S354
JournalJournal of Infectious Diseases
Volume228
DOIs
Publication statusPublished - 1 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

  • 3D tissue models
  • SARS-CoV-2
  • antiviral drug discovery
  • body-on-a-chip
  • human pluripotent stem cells (hPSCs)
  • induced pluripotent stem cells (iPSCs)
  • microphysiological systems (MPS)
  • organ-on-a-chip
  • organoid
  • tissue-derived stem cells

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