Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium

S. A. Gray; G. N. Stradling; M. J. Pearce; I. Wilson; J. C. Moody; R. Burgada; P. W. Durbin; K. N. Raymond

doi:10.1093/oxfordjournals.rpd.a082301

Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium

S. A. Gray^*, G. N. Stradling, M. J. Pearce, I. Wilson, J. C. Moody, R. Burgada, P. W. Durbin, K. N. Raymond

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous and intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg^-1 body mass.

Original language	English
Pages (from-to)	319-322
Number of pages	4
Journal	Radiation Protection Dosimetry
Volume	53
Issue number	1-4
DOIs	https://doi.org/10.1093/oxfordjournals.rpd.a082301
Publication status	Published - 1994

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Gray, S. A., Stradling, G. N., Pearce, M. J., Wilson, I., Moody, J. C., Burgada, R., Durbin, P. W., & Raymond, K. N. (1994). Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium. Radiation Protection Dosimetry, 53(1-4), 319-322. https://doi.org/10.1093/oxfordjournals.rpd.a082301

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title = "Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium",

abstract = "The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous and intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg-1 body mass.",

author = "Gray, {S. A.} and Stradling, {G. N.} and Pearce, {M. J.} and I. Wilson and Moody, {J. C.} and R. Burgada and Durbin, {P. W.} and Raymond, {K. N.}",

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doi = "10.1093/oxfordjournals.rpd.a082301",

language = "English",

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Gray, SA, Stradling, GN, Pearce, MJ, Wilson, I, Moody, JC, Burgada, R, Durbin, PW & Raymond, KN 1994, 'Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium', Radiation Protection Dosimetry, vol. 53, no. 1-4, pp. 319-322. https://doi.org/10.1093/oxfordjournals.rpd.a082301

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T1 - Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination

T2 - Effect of delayed administration and mass of plutonium

AU - Gray, S. A.

AU - Stradling, G. N.

AU - Pearce, M. J.

AU - Wilson, I.

AU - Moody, J. C.

AU - Burgada, R.

AU - Durbin, P. W.

AU - Raymond, K. N.

PY - 1994

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N2 - The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous and intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg-1 body mass.

AB - The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous and intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg-1 body mass.

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Removal of plutonium and Americium from the rat using 3,4,3-LIHOPO and DTPA after simulated wound contamination: Effect of delayed administration and mass of plutonium

Abstract

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