Relative risk of abnormal karyotype in fetuses found to have an atrioventricular septal defect (AVSD) on fetal echocardiography

Kate Langford, Gurleen Sharland, John Simpson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

One hundred and twenty-five fetuses were identified as having an AVSD with normal venous connections, normal arterial connections and normal cardiac situs on fetal echocardiography. Fetal karyotype was known in 111 of these cases. The relative risk of fetal trisomy 21 at mid-trimester was 107 (95% CI 87-127) times the expected number of cases compared with risk from maternal age alone, and that for trisomy 21, 18 or 13 was 95 (95% CI 79-109). This data may be useful in counselling pregnant women about risk of fetal karyotypic abnormality after a diagnosis of fetal AVSD.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalPrenatal Diagnosis
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Keywords

  • Atrioventricular septal defect
  • Fetal heart
  • Karyotype
  • Prenatal diagnosis

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