Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers

Derek Bingham; Bérard Philippe Bérard; Alan Birchall; Richard Bull; Elisabeth Cardis; Cécile Challeton De Vathaire; James Grellier; Christian Hurtgen; Matthew Puncher; Anthony Riddell; Isabelle Thierry-Chef

doi:10.1093/rpd/ncw227

Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers

Derek Bingham^*, Bérard Philippe Bérard, Alan Birchall, Richard Bull, Elisabeth Cardis, Cécile Challeton De Vathaire, James Grellier, Christian Hurtgen, Matthew Puncher, Anthony Riddell, Isabelle Thierry-Chef

^*Corresponding author for this work

Radiation Hazards & Emergencies

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.

Original language	English
Pages (from-to)	485-494
Number of pages	10
Journal	Radiation Protection Dosimetry
Volume	174
Issue number	4
DOIs	https://doi.org/10.1093/rpd/ncw227
Publication status	Published - 1 May 2017

Bibliographical note

Funding Information:
This work was supported by the European Commission (EC) under the 6th Framework Programme (FP6) of the European Atomic Energy Community (EURATOM) for nuclear research and training activities as a Specific Targeted Research Programme (STREP) entitled '?-Risk: quantification of cancer and non-cancer risks associated with multiple chronic radiation exposures: Epidemiological studies, organ dose calculation and risk assessment' [grant number 516483].

Publisher Copyright:
© Crown copyright 2016.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/rpd/ncw227

Cite this

Bingham, D., Philippe Bérard, B., Birchall, A., Bull, R., Cardis, E., De Vathaire, C. C., Grellier, J., Hurtgen, C., Puncher, M., Riddell, A., & Thierry-Chef, I. (2017). Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers. Radiation Protection Dosimetry, 174(4), 485-494. https://doi.org/10.1093/rpd/ncw227

@article{3599dcc32a644d0eaa7b275edae6add8,

title = "Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers",

abstract = "The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.",

author = "Derek Bingham and {Philippe B{\'e}rard}, B{\'e}rard and Alan Birchall and Richard Bull and Elisabeth Cardis and {De Vathaire}, {C{\'e}cile Challeton} and James Grellier and Christian Hurtgen and Matthew Puncher and Anthony Riddell and Isabelle Thierry-Chef",

note = "Funding Information: This work was supported by the European Commission (EC) under the 6th Framework Programme (FP6) of the European Atomic Energy Community (EURATOM) for nuclear research and training activities as a Specific Targeted Research Programme (STREP) entitled '?-Risk: quantification of cancer and non-cancer risks associated with multiple chronic radiation exposures: Epidemiological studies, organ dose calculation and risk assessment' [grant number 516483]. Publisher Copyright: {\textcopyright} Crown copyright 2016.",

year = "2017",

month = may,

day = "1",

doi = "10.1093/rpd/ncw227",

language = "English",

volume = "174",

pages = "485--494",

journal = "Radiation Protection Dosimetry",

issn = "0144-8420",

publisher = "Oxford University Press",

number = "4",

}

Bingham, D, Philippe Bérard, B, Birchall, A, Bull, R, Cardis, E, De Vathaire, CC, Grellier, J, Hurtgen, C, Puncher, M, Riddell, A & Thierry-Chef, I 2017, 'Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers', Radiation Protection Dosimetry, vol. 174, no. 4, pp. 485-494. https://doi.org/10.1093/rpd/ncw227

TY - JOUR

T1 - Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers

AU - Bingham, Derek

AU - Philippe Bérard, Bérard

AU - Birchall, Alan

AU - Bull, Richard

AU - Cardis, Elisabeth

AU - De Vathaire, Cécile Challeton

AU - Grellier, James

AU - Hurtgen, Christian

AU - Puncher, Matthew

AU - Riddell, Anthony

AU - Thierry-Chef, Isabelle

N1 - Funding Information: This work was supported by the European Commission (EC) under the 6th Framework Programme (FP6) of the European Atomic Energy Community (EURATOM) for nuclear research and training activities as a Specific Targeted Research Programme (STREP) entitled '?-Risk: quantification of cancer and non-cancer risks associated with multiple chronic radiation exposures: Epidemiological studies, organ dose calculation and risk assessment' [grant number 516483]. Publisher Copyright: © Crown copyright 2016.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.

AB - The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.

UR - http://www.scopus.com/inward/record.url?scp=85028837398&partnerID=8YFLogxK

U2 - 10.1093/rpd/ncw227

DO - 10.1093/rpd/ncw227

M3 - Article

C2 - 27522044

AN - SCOPUS:85028837398

SN - 0144-8420

VL - 174

SP - 485

EP - 494

JO - Radiation Protection Dosimetry

JF - Radiation Protection Dosimetry

IS - 4

ER -

Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this