Reconstruction of internal doses for the alpha-risk case-control study of lung cancer and leukaemia among european nuclear workers

Derek Bingham*, Bérard Philippe Bérard, Alan Birchall, Richard Bull, Elisabeth Cardis, Cécile Challeton De Vathaire, James Grellier, Christian Hurtgen, Matthew Puncher, Anthony Riddell, Isabelle Thierry-Chef

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalRadiation Protection Dosimetry
Issue number4
Publication statusPublished - 1 May 2017

Bibliographical note

Funding Information:
This work was supported by the European Commission (EC) under the 6th Framework Programme (FP6) of the European Atomic Energy Community (EURATOM) for nuclear research and training activities as a Specific Targeted Research Programme (STREP) entitled '?-Risk: quantification of cancer and non-cancer risks associated with multiple chronic radiation exposures: Epidemiological studies, organ dose calculation and risk assessment' [grant number 516483].

Publisher Copyright:
© Crown copyright 2016.


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