Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

David E. Minnikin; Oona Y.C. Lee; Houdini H.T. Wu; Gurdyal S. Besra; Helen D. Donoghue

doi:10.1177/0959683619895572

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

David E. Minnikin^*
, Oona Y.C. Lee
, Houdini H.T. Wu
, Gurdyal S. Besra
, Helen D. Donoghue

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

1 Citation (Scopus)

Abstract

The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

Original language	English
Pages (from-to)	781-783
Number of pages	3
Journal	Holocene
Volume	30
Issue number	5
DOIs	https://doi.org/10.1177/0959683619895572
Publication status	Published - 1 May 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA fragment amplification
Pleistocene megafauna
ancient tuberculosis
genomes
lipid biomarkers
paleopathology
tuberculosis evolution

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title = "Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on {\textquoteleft}Infectious diseases and Neolithic transformations{\textquoteright} (Fuchs et al. 2019 The Holocene 29: 1545–1557)",

abstract = "The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.",

keywords = "DNA fragment amplification, Pleistocene megafauna, ancient tuberculosis, genomes, lipid biomarkers, paleopathology, tuberculosis evolution",

author = "Minnikin, \{David E.\} and Lee, \{Oona Y.C.\} and Wu, \{Houdini H.T.\} and Besra, \{Gurdyal S.\} and Donoghue, \{Helen D.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2020.",

year = "2020",

month = may,

day = "1",

doi = "10.1177/0959683619895572",

language = "English",

volume = "30",

pages = "781--783",

journal = "Holocene",

issn = "0959-6836",

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number = "5",

}

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557). / Minnikin, David E.; Lee, Oona Y.C.; Wu, Houdini H.T. et al.
In: Holocene, Vol. 30, No. 5, 01.05.2020, p. 781-783.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis

T2 - Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

AU - Minnikin, David E.

AU - Lee, Oona Y.C.

AU - Wu, Houdini H.T.

AU - Besra, Gurdyal S.

AU - Donoghue, Helen D.

N1 - Publisher Copyright: © The Author(s) 2020.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

AB - The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

KW - DNA fragment amplification

KW - Pleistocene megafauna

KW - ancient tuberculosis

KW - genomes

KW - lipid biomarkers

KW - paleopathology

KW - tuberculosis evolution

UR - https://www.scopus.com/pages/publications/85077911097

U2 - 10.1177/0959683619895572

DO - 10.1177/0959683619895572

M3 - Comment/debate

AN - SCOPUS:85077911097

SN - 0959-6836

VL - 30

SP - 781

EP - 783

JO - Holocene

JF - Holocene

IS - 5

ER -

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557)

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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