Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

EUROCARE-5 Working Group, Magdalena Bielska-Lasota, Silvia Rossi, Michalina Krzyżak, Annemie Haelens, Augius Domenic, Roberta De Angelis, Adam Maciejczyk, Miguel Rodríguez-Barranco, Vesna Zadnik, Pamela Minicozzi, J. Rashbass, J. Broggio, J. Verne

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Purpose: With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis (local, regional and metastatic), morphology (mainly squamous versus glandular tumours) and patients’ age. 

    Methods: We analysed 101,714 CC women diagnosed in 2000–2007 and followed-up to December 2008. Age-standardised 5-year relative survival (RS) and the excess risks of cancer death in the 5 years after diagnosis were computed. 

    Results: EE women were older and less commonly diagnosed with glandular tumours. Proportions of local stage cancers were similar across Europe, while morphology- and stage-specific RS (especially for non-metastatic disease) were lower in Eastern Europe. Adjusting for age and morphology, excess risk of local stage CC death for EE patients remained higher than that for other European women. 

    Conclusion: Stage, age and morphology alone do not explain worse survival in Eastern Europe: less effective care may play a role, probably partly due to fewer or inadequate resources being allocated to health care in this area, compared to the rest of Europe.

    Original languageEnglish
    Pages (from-to)591-602
    Number of pages12
    JournalArchives of Gynecology and Obstetrics
    Volume301
    Issue number2
    Early online date18 Dec 2019
    DOIs
    Publication statusPublished - 1 Feb 2020

    Bibliographical note

    Funding Information: The authors declare that they have no conflict of
    interest.

    Open Access: No Open Access licence.

    Publisher Copyright: © Springer-Verlag GmbH Germany, part of Springer Nature 2019.

    Citation: Bielska-Lasota, M., Rossi, S., Krzyżak, M. et al. Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study. Arch Gynecol Obstet 301, 591–602 (2020).

    DOI: https://doi.org/10.1007/s00404-019-05412-5

    Keywords

    • Cervical cancer
    • Europe
    • Morphology
    • Population-based study
    • Stage at diagnosis
    • Survival

    Fingerprint

    Dive into the research topics of 'Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study'. Together they form a unique fingerprint.

    Cite this