Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

D. Ashley Robinson; Angela Kearns; Anne Holmes; Donald Morrison; Hajo Grundmann; Giles Edwards; Frances G. O'Brien; Fred C. Tenover; Linda K. McDougal; Alastair B. Monk; Mark C. Enright

doi:10.1016/S0140-6736(05)74814-5

Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

D. Ashley Robinson, Angela Kearns, Anne Holmes, Donald Morrison, Hajo Grundmann, Giles Edwards, Frances G. O'Brien, Fred C. Tenover, Linda K. McDougal, Alastair B. Monk, Mark C. Enright^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

233 Citations (Scopus)

Abstract

During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant β lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

Original language	English
Pages (from-to)	1256-1258
Number of pages	3
Journal	The Lancet
Volume	365
Issue number	9466
DOIs	https://doi.org/10.1016/S0140-6736(05)74814-5
Publication status	Published - 2 Apr 2005

Bibliographical note

Funding Information:
This work was supported by the Wellcome Trust. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

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title = "Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone",

abstract = "During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant β lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.",

author = "Robinson, {D. Ashley} and Angela Kearns and Anne Holmes and Donald Morrison and Hajo Grundmann and Giles Edwards and O'Brien, {Frances G.} and Tenover, {Fred C.} and McDougal, {Linda K.} and Monk, {Alastair B.} and Enright, {Mark C.}",

note = "Funding Information: This work was supported by the Wellcome Trust. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.",

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AU - Kearns, Angela

AU - Holmes, Anne

AU - Morrison, Donald

AU - Grundmann, Hajo

AU - Edwards, Giles

AU - O'Brien, Frances G.

AU - Tenover, Fred C.

AU - McDougal, Linda K.

AU - Monk, Alastair B.

AU - Enright, Mark C.

N1 - Funding Information: This work was supported by the Wellcome Trust. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

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ER -

Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

Abstract

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