Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak

M. Estée Török; Sandra Reuter; Josephine Bryant; Claudio U. Köser; Sian V. Stinchcombe; Bernadette Nazareth; Matthew Ellington; Stephen D. Bentley; Geoffrey P. Smith; Julian Parkhill; Sharon J. Peacock

doi:10.1128/JCM.02279-12

Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak

M. Estée Török^*, Sandra Reuter, Josephine Bryant, Claudio U. Köser, Sian V. Stinchcombe, Bernadette Nazareth, Matthew Ellington, Stephen D. Bentley, Geoffrey P. Smith, Julian Parkhill, Sharon J. Peacock

^*Corresponding author for this work

ARMHAI Reference Lab

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1128/JCM.02279-12
Publication status	Published - Feb 2013

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10.1128/JCM.02279-12

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title = "Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak",

abstract = "Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.",

author = "{Est{\'e}e T{\"o}r{\"o}k}, M. and Sandra Reuter and Josephine Bryant and K{\"o}ser, {Claudio U.} and Stinchcombe, {Sian V.} and Bernadette Nazareth and Matthew Ellington and Bentley, {Stephen D.} and Smith, {Geoffrey P.} and Julian Parkhill and Peacock, {Sharon J.}",

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AU - Estée Török, M.

AU - Reuter, Sandra

AU - Bryant, Josephine

AU - Köser, Claudio U.

AU - Stinchcombe, Sian V.

AU - Nazareth, Bernadette

AU - Ellington, Matthew

AU - Bentley, Stephen D.

AU - Smith, Geoffrey P.

AU - Parkhill, Julian

AU - Peacock, Sharon J.

PY - 2013/2

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AB - Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.

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ER -

Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak

Abstract

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