Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ

K. Clements, D. Dodwell*, Gillian Lawrence, G. Ball, A. Francis, S. Pinder, E. Sawyer, M. Wallis, A. M. Thompson

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)


    Background A role for radiotherapy after mastectomy for ductal carcinoma in situ (DCIS) is unclear. Using a prospective audit of DCIS detected through the NHS Breast Screening Programme we sought to determine a rationale for the use of post mastectomy radiotherapy for DCIS. Methods Over a nine year period, from 9972 patients with screen-detected DCIS and complete surgical, pathology, radiotherapy and follow up data, 2944 women underwent mastectomy for DCIS of whom 33 (1.1%) received radiotherapy. Results Use of post mastectomy radiotherapy was significantly associated with a close (<1 mm) pathology margin (χ2(1) 95.81; p < 0.00001), DCIS size (χ2 (3) 16.96; p < 0.001) and the presence of microinvasion (χ2(1) 3.92; p < 0.05). At a median follow up 61 months, no woman who received radiotherapy had an ipsilateral further event, and only 1/33 women (3.0%) had a contralateral event. Of the women known not to have had radiotherapy post mastectomy, 45/2894 (1.6%) had an ipsilateral further event and 83 (2.9%) had a contralateral event. Conclusion Recurrence following mastectomy for DCIS is rare. A close (<1 mm) margin, large tumour size and microinvasion, may merit radiotherapy to reduce ipsilateral recurrence.

    Original languageEnglish
    Article number4120
    Pages (from-to)1406-1410
    Number of pages5
    JournalEuropean Journal of Surgical Oncology
    Issue number10
    Publication statusPublished - Oct 2015

    Bibliographical note

    Publisher Copyright:
    © 2015 Elsevier Ltd.


    • Breast cancer
    • DCIS
    • Mastectomy
    • Radiotherapy
    • Sloane project


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