Quality of life and associated socio-clinical factors after encephalitis in children and adults in England: A population-based, prospective cohort study

Parashar Pravin Ramanuj, Julia Granerod, Nicholas W.S. Davies, Stefano Conti, David Brown, Natasha S. Crowcroft

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Objective: We sought to measure HRQoL in all-cause encephalitis survivors and assess the impact of various socio-clinical factors on outcome. Methods: We used a prospective cohort study design, using the short-form 36 (SF-36) to measure the HRQoL in patients 15 years and older, and the short-form 10 (SF-10) for patients less than 15 years old. We posted questionnaires to individuals six months after discharge from hospital. All scores were normalised to the age- and sex-matched general population. We used multivariate statistical analysis to assess the relative association of clinical and socio-demographic variables on HRQoL in adults. Results: Of 109 individuals followed-up, we received 61 SF-36 and twenty SF-10 questionnaires (response rate 74%). Patients scored consistently worse than the general population in all domains of the SF-36 and SF-10, although there was variation in individual scores. Infectious encephalitis was associated with the worst HRQoL in those aged 15 years and over, scoring on average 5.64 points less than immune-mediated encephalitis (95% CI -8.77- -2.89). In those aged less than 15 years the worst quality of life followed encephalitis of unknown cause. Immuno compromise, unemployment, and the 35-44 age group all had an independent negative association with HRQoL. A poor Glasgow Outcome Score was most strongly associated with a poor HRQoL. Less than half of those who had made a 'good' recovery on the score reported a HRQoL equivalent to the general population. Conclusions: Encephalitis has adverse effects on the majority of survivors' wellbeing and quality of life. Many of these adverse consequences could be minimised by prompt identification and treatment, and with better rehabilitation and support for survivors.

Original languageEnglish
Article numbere103496
JournalPLoS ONE
Volume9
Issue number7
DOIs
Publication statusPublished - 29 Jul 2014

Fingerprint

Dive into the research topics of 'Quality of life and associated socio-clinical factors after encephalitis in children and adults in England: A population-based, prospective cohort study'. Together they form a unique fingerprint.

Cite this