Q fever outbreak in industrial setting

Hugo C. Van Woerden; Brendan W. Mason; Lika K. Nehaul; Robert Smith; Roland L. Salmon; Brendan Healy; Manoj Valappil; Diana Westmoreland; Sarah De Martin; Meirion R. Evans; Graham Lloyd; Marysia Hamilton-Kirkwood; Nina S. Williams

doi:10.3201/eid1007.030536

Q fever outbreak in industrial setting

Hugo C. Van Woerden^*, Brendan W. Mason, Lika K. Nehaul, Robert Smith, Roland L. Salmon, Brendan Healy, Manoj Valappil, Diana Westmoreland, Sarah De Martin, Meirion R. Evans, Graham Lloyd, Marysia Hamilton-Kirkwood, Nina S. Williams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. Ninety-five cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board.

Original language	English
Pages (from-to)	1282-1289
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	10
Issue number	7
DOIs	https://doi.org/10.3201/eid1007.030536
Publication status	Published - Jul 2004

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title = "Q fever outbreak in industrial setting",

abstract = "An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. Ninety-five cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board.",

author = "{Van Woerden}, {Hugo C.} and Mason, {Brendan W.} and Nehaul, {Lika K.} and Robert Smith and Salmon, {Roland L.} and Brendan Healy and Manoj Valappil and Diana Westmoreland and {De Martin}, Sarah and Evans, {Meirion R.} and Graham Lloyd and Marysia Hamilton-Kirkwood and Williams, {Nina S.}",

year = "2004",

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pages = "1282--1289",

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AU - Van Woerden, Hugo C.

AU - Mason, Brendan W.

AU - Nehaul, Lika K.

AU - Smith, Robert

AU - Salmon, Roland L.

AU - Healy, Brendan

AU - Valappil, Manoj

AU - Westmoreland, Diana

AU - De Martin, Sarah

AU - Evans, Meirion R.

AU - Lloyd, Graham

AU - Hamilton-Kirkwood, Marysia

AU - Williams, Nina S.

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N2 - An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. Ninety-five cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board.

AB - An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. Ninety-five cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board.

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JO - Emerging Infectious Diseases

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Q fever outbreak in industrial setting

Abstract

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