TY - JOUR
T1 - Psychological stress and the common cold
AU - Gwaltney, Jack M.
AU - Hayden, Frederick G.
AU - Chester, Alexander C.
AU - Cohen, Sheldon
AU - Tyrrell, David A.j.
AU - Smith, Andrew P.
PY - 1992/2/27
Y1 - 1992/2/27
N2 - To the Editor: The conclusion of Cohen et al. (Aug. 29 issue)1 that stress increases infection rates after an experimental rhinovirus challenge cannot be accepted on the basis of the results presented. Persons with low or absent titers (≥2) of serum neutralizing antibody almost always become infected after an intranasal rhinovirus challenge. In our trials over the past 13 years, 321 of 343 susceptible (i.e., with titers ≥2) control subjects (94 percent) became infected after a challenge.2 3 4 5 6 7 8 9 10 11 12 13 14 15 In the study of Cohen et al., infection rates in the antibody-free subjects with high and low scores on the psychological-stress index were.
AB - To the Editor: The conclusion of Cohen et al. (Aug. 29 issue)1 that stress increases infection rates after an experimental rhinovirus challenge cannot be accepted on the basis of the results presented. Persons with low or absent titers (≥2) of serum neutralizing antibody almost always become infected after an intranasal rhinovirus challenge. In our trials over the past 13 years, 321 of 343 susceptible (i.e., with titers ≥2) control subjects (94 percent) became infected after a challenge.2 3 4 5 6 7 8 9 10 11 12 13 14 15 In the study of Cohen et al., infection rates in the antibody-free subjects with high and low scores on the psychological-stress index were.
UR - https://www.scopus.com/pages/publications/0026585204
U2 - 10.1056/NEJM199202273260915
DO - 10.1056/NEJM199202273260915
M3 - Letter
C2 - 1310349
AN - SCOPUS:0026585204
SN - 0028-4793
VL - 326
SP - 644
EP - 646
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 9
ER -