Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model

Anja W. Olsen; Ann Williams; Limei M. Okkels; Graham Hatch; Peter Andersen

doi:10.1128/IAI.72.10.6148-6150.2004

Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model

Anja W. Olsen
, Ann Williams
, Limei M. Okkels
, Graham Hatch
, Peter Andersen^*

^*Corresponding author for this work

Biological Investigations Group

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

Abstract

A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.

Original language	English
Pages (from-to)	6148-6150
Number of pages	3
Journal	Infection and Immunity
Volume	72
Issue number	10
DOIs	https://doi.org/10.1128/IAI.72.10.6148-6150.2004
Publication status	Published - Oct 2004

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SDG 3 Good Health and Well-being

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10.1128/IAI.72.10.6148-6150.2004

Cite this

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title = "Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model",

abstract = "A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.",

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AU - Olsen, Anja W.

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AU - Okkels, Limei M.

AU - Hatch, Graham

AU - Andersen, Peter

PY - 2004/10

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N2 - A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.

AB - A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.

UR - https://www.scopus.com/pages/publications/4644235020

U2 - 10.1128/IAI.72.10.6148-6150.2004

DO - 10.1128/IAI.72.10.6148-6150.2004

M3 - Article

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AN - SCOPUS:4644235020

SN - 0019-9567

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JO - Infection and Immunity

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IS - 10

ER -

Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model

Abstract

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