Protection studies in mice immunized with B. pertussis fimbriae formulated in biodegradable microparticles

D. H. Jones*, Simon Funnell, H. Jeffery, D. T. O'Hagan, A. Robinson, G. H. Farrar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The optimal conditions for the encapsulation of fimbriae from B. pertussis in poly(lactide-co-glycolide)(PLG) microspheres have been determined. The binding of a panel of antibodies which react with conformational or linear fimbrial epitopes, to fimbriae released from microspheres, suggested that the process of microencapsulation was not detrimental to the native integrity of the protein. A single i.p. injection of microencapsulated fimbriae, protected mice against challenge with live B. pertussis for a period of up to six months after immunization, to a degree comparable to that achieved by fimbriae adsorbed onto alum.

Original languageEnglish
Title of host publicationInstitution of Chemical Engineers Symposium Series
Editors Anon
PublisherPubl by Inst of Chemical Engineers
Pages28-30
Number of pages3
ISBN (Print)0852953356
Publication statusPublished - 1994
EventProceedings of the 2nd Conference on Industrial Immunology - Brighton, UK
Duration: 4 Jul 19945 Jul 1994

Publication series

NameInstitution of Chemical Engineers Symposium Series
ISSN (Print)0307-0492

Conference

ConferenceProceedings of the 2nd Conference on Industrial Immunology
CityBrighton, UK
Period4/07/945/07/94

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