Protection, pathogenesis and phenotypic plasticity in Plasmodium falciparum malaria

D. J. Roberts; B. A. Biggs; G. Brown; C. I. Newbold

doi:10.1016/0169-4758(93)90121-U

Protection, pathogenesis and phenotypic plasticity in Plasmodium falciparum malaria

D. J. Roberts^*
, B. A. Biggs
, G. Brown
, C. I. Newbold

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

52 Citations (Scopus)

Abstract

Why does Plasmodium falciparum cause severe illness in some but not all infections? How is clinical immunity acquired? These questions have intrigued investigators since the clinical epidemiology of malaria was first described. The search for answers to both questions has highlighted the changes that take place at the surface of infected red blood cells during the last half of the erythrocytic cycle. These changes specify the antigenic and adhesive or cytoadherence phenotypes for the infected cell. Now the antigenic and adhesive phenotypes appear to be linked and together undergo clonal variation. In this article David Roberts, Beverley-Ann Biggs, Graham Brown and Christopher Newbold explain how clonal phenotypic variation and the linkage between adhesive and antigenic types contribute to our understanding of naturally acquired immunity and of pathogenesis of severe malaria.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	Parasitology Today
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/0169-4758(93)90121-U
Publication status	Published - Aug 1993
Externally published	Yes

Bibliographical note

Funding Information:
The authors would like to acknowledge their discussions with Tony Berendt, Kevin Harsh, Robin Anders and Ross Coppel and thank David Ferguson for providing electron micrographs. DJR is a Medical Research Council Training Fellow. BB is a Keir Fellow of the Royal Melbourne Hospital. This work was supported by the Medical Research Council, the Weltcome Trust, The National Health and Medical Research Council of Australia and the John D. and Catherine T. MacArthur Foundation.

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SDG 3 Good Health and Well-being

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10.1016/0169-4758(93)90121-U

Cite this

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title = "Protection, pathogenesis and phenotypic plasticity in Plasmodium falciparum malaria",

abstract = "Why does Plasmodium falciparum cause severe illness in some but not all infections? How is clinical immunity acquired? These questions have intrigued investigators since the clinical epidemiology of malaria was first described. The search for answers to both questions has highlighted the changes that take place at the surface of infected red blood cells during the last half of the erythrocytic cycle. These changes specify the antigenic and adhesive or cytoadherence phenotypes for the infected cell. Now the antigenic and adhesive phenotypes appear to be linked and together undergo clonal variation. In this article David Roberts, Beverley-Ann Biggs, Graham Brown and Christopher Newbold explain how clonal phenotypic variation and the linkage between adhesive and antigenic types contribute to our understanding of naturally acquired immunity and of pathogenesis of severe malaria.",

author = "Roberts, \{D. J.\} and Biggs, \{B. A.\} and G. Brown and Newbold, \{C. I.\}",

note = "Funding Information: The authors would like to acknowledge their discussions with Tony Berendt, Kevin Harsh, Robin Anders and Ross Coppel and thank David Ferguson for providing electron micrographs. DJR is a Medical Research Council Training Fellow. BB is a Keir Fellow of the Royal Melbourne Hospital. This work was supported by the Medical Research Council, the Weltcome Trust, The National Health and Medical Research Council of Australia and the John D. and Catherine T. MacArthur Foundation.",

year = "1993",

month = aug,

doi = "10.1016/0169-4758(93)90121-U",

language = "English",

volume = "9",

pages = "281--286",

journal = "Parasitology Today",

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AU - Roberts, D. J.

AU - Biggs, B. A.

AU - Brown, G.

AU - Newbold, C. I.

N1 - Funding Information: The authors would like to acknowledge their discussions with Tony Berendt, Kevin Harsh, Robin Anders and Ross Coppel and thank David Ferguson for providing electron micrographs. DJR is a Medical Research Council Training Fellow. BB is a Keir Fellow of the Royal Melbourne Hospital. This work was supported by the Medical Research Council, the Weltcome Trust, The National Health and Medical Research Council of Australia and the John D. and Catherine T. MacArthur Foundation.

PY - 1993/8

Y1 - 1993/8

N2 - Why does Plasmodium falciparum cause severe illness in some but not all infections? How is clinical immunity acquired? These questions have intrigued investigators since the clinical epidemiology of malaria was first described. The search for answers to both questions has highlighted the changes that take place at the surface of infected red blood cells during the last half of the erythrocytic cycle. These changes specify the antigenic and adhesive or cytoadherence phenotypes for the infected cell. Now the antigenic and adhesive phenotypes appear to be linked and together undergo clonal variation. In this article David Roberts, Beverley-Ann Biggs, Graham Brown and Christopher Newbold explain how clonal phenotypic variation and the linkage between adhesive and antigenic types contribute to our understanding of naturally acquired immunity and of pathogenesis of severe malaria.

AB - Why does Plasmodium falciparum cause severe illness in some but not all infections? How is clinical immunity acquired? These questions have intrigued investigators since the clinical epidemiology of malaria was first described. The search for answers to both questions has highlighted the changes that take place at the surface of infected red blood cells during the last half of the erythrocytic cycle. These changes specify the antigenic and adhesive or cytoadherence phenotypes for the infected cell. Now the antigenic and adhesive phenotypes appear to be linked and together undergo clonal variation. In this article David Roberts, Beverley-Ann Biggs, Graham Brown and Christopher Newbold explain how clonal phenotypic variation and the linkage between adhesive and antigenic types contribute to our understanding of naturally acquired immunity and of pathogenesis of severe malaria.

UR - https://www.scopus.com/pages/publications/0027293916

U2 - 10.1016/0169-4758(93)90121-U

DO - 10.1016/0169-4758(93)90121-U

M3 - Review article

AN - SCOPUS:0027293916

SN - 0169-4758

VL - 9

SP - 281

EP - 286

JO - Parasitology Today

JF - Parasitology Today

IS - 8

ER -

Protection, pathogenesis and phenotypic plasticity in Plasmodium falciparum malaria

Abstract

Bibliographical note

UN SDGs

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