TY - JOUR
T1 - Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK
AU - the COVID-19 Infection Survey team
AU - Wei, Jia
AU - Matthews, Philippa C.
AU - Stoesser, Nicole
AU - Newton, John N.
AU - Diamond, Ian
AU - Studley, Ruth
AU - Taylor, Nick
AU - Bell, John I.
AU - Farrar, Jeremy
AU - Kolenchery, Jaison
AU - Marsden, Brian D.
AU - Hoosdally, Sarah
AU - Jones, E. Yvonne
AU - Stuart, David I.
AU - Crook, Derrick W.
AU - Peto, Tim E.A.
AU - Walker, A. Sarah
AU - Pouwels, Koen B.
AU - Eyre, David W.
AU - Thomas, Tina
AU - Ayoubkhani, Daniel
AU - Black, Russell
AU - Felton, Antonio
AU - Crees, Megan
AU - Jones, Joel
AU - Lloyd, Lina
AU - Sutherland, Esther
AU - Pritchard, Emma
AU - Vihta, Karina Doris
AU - Doherty, George
AU - Kavanagh, James
AU - Chau, Kevin K.
AU - Hatch, Stephanie B.
AU - Ebner, Daniel
AU - Ferreira, Lucas Martins
AU - Christott, Thomas
AU - Dejnirattisai, Wanwisa
AU - Mongkolsapaya, Juthathip
AU - Cameron, Sarah
AU - Tamblin-Hopper, Phoebe
AU - Wolna, Magda
AU - Brown, Rachael
AU - Cornall, Richard
AU - Screaton, Gavin
AU - Lythgoe, Katrina
AU - Bonsall, David
AU - Golubchik, Tanya
AU - Fryer, Helen
AU - Robotham, Julie
AU - Birrell, Paul
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Following primary SARS-CoV-2 vaccination, whether boosters or breakthrough infections provide greater protection against SARS-CoV-2 infection is incompletely understood. Here we investigated SARS-CoV-2 antibody correlates of protection against new Omicron BA.4/5 (re-)infections and anti-spike IgG antibody trajectories after a third/booster vaccination or breakthrough infection following second vaccination in 154,149 adults ≥18 y from the United Kingdom general population. Higher antibody levels were associated with increased protection against Omicron BA.4/5 infection and breakthrough infections were associated with higher levels of protection at any given antibody level than boosters. Breakthrough infections generated similar antibody levels to boosters, and the subsequent antibody declines were slightly slower than after boosters. Together our findings show breakthrough infection provides longer-lasting protection against further infections than booster vaccinations. Our findings, considered alongside the risks of severe infection and long-term consequences of infection, have important implications for vaccine policy.
AB - Following primary SARS-CoV-2 vaccination, whether boosters or breakthrough infections provide greater protection against SARS-CoV-2 infection is incompletely understood. Here we investigated SARS-CoV-2 antibody correlates of protection against new Omicron BA.4/5 (re-)infections and anti-spike IgG antibody trajectories after a third/booster vaccination or breakthrough infection following second vaccination in 154,149 adults ≥18 y from the United Kingdom general population. Higher antibody levels were associated with increased protection against Omicron BA.4/5 infection and breakthrough infections were associated with higher levels of protection at any given antibody level than boosters. Breakthrough infections generated similar antibody levels to boosters, and the subsequent antibody declines were slightly slower than after boosters. Together our findings show breakthrough infection provides longer-lasting protection against further infections than booster vaccinations. Our findings, considered alongside the risks of severe infection and long-term consequences of infection, have important implications for vaccine policy.
UR - http://www.scopus.com/inward/record.url?scp=85159466757&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-38275-1
DO - 10.1038/s41467-023-38275-1
M3 - Article
C2 - 37193713
AN - SCOPUS:85159466757
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2799
ER -