Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand

Rapeephan R. Maude; Teerapon Vatcharapreechasakul; Pitchayanant Ariyaprasert; Richard J. Maude; Maliwan Hongsuwan; Prayoon Yuentrakul; Direk Limmathurotsakul; Gavin C.K.W. Koh; Wipada Chaowagul; Nicholas P.J. Day; Sharon J. Peacock

doi:10.1016/j.trstmh.2012.05.007

Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand

Rapeephan R. Maude^*, Teerapon Vatcharapreechasakul, Pitchayanant Ariyaprasert, Richard J. Maude, Maliwan Hongsuwan, Prayoon Yuentrakul, Direk Limmathurotsakul, Gavin C.K.W. Koh, Wipada Chaowagul, Nicholas P.J. Day, Sharon J. Peacock

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).

Original language	English
Pages (from-to)	629-631
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	106
Issue number	10
DOIs	https://doi.org/10.1016/j.trstmh.2012.05.007
Publication status	Published - Oct 2012
Externally published	Yes

Bibliographical note

Funding Information:
This study was funded by the Wellcome Trust, London, UK (Grant number 087460/Z/08/Z).

Keywords

Abscess
Burkholderia pseudomallei
Liver
Melioidosis
Spleen
Ultrasound

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trstmh.2012.05.007

Cite this

Maude, R. R., Vatcharapreechasakul, T., Ariyaprasert, P., Maude, R. J., Hongsuwan, M., Yuentrakul, P., Limmathurotsakul, D., Koh, G. C. K. W., Chaowagul, W., Day, N. P. J., & Peacock, S. J. (2012). Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106(10), 629-631. https://doi.org/10.1016/j.trstmh.2012.05.007

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title = "Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand",

abstract = "Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).",

keywords = "Abscess, Burkholderia pseudomallei, Liver, Melioidosis, Spleen, Ultrasound",

author = "Maude, {Rapeephan R.} and Teerapon Vatcharapreechasakul and Pitchayanant Ariyaprasert and Maude, {Richard J.} and Maliwan Hongsuwan and Prayoon Yuentrakul and Direk Limmathurotsakul and Koh, {Gavin C.K.W.} and Wipada Chaowagul and Day, {Nicholas P.J.} and Peacock, {Sharon J.}",

note = "Funding Information: This study was funded by the Wellcome Trust, London, UK (Grant number 087460/Z/08/Z). ",

year = "2012",

month = oct,

doi = "10.1016/j.trstmh.2012.05.007",

language = "English",

volume = "106",

pages = "629--631",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

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Maude, RR, Vatcharapreechasakul, T, Ariyaprasert, P, Maude, RJ, Hongsuwan, M, Yuentrakul, P, Limmathurotsakul, D, Koh, GCKW, Chaowagul, W, Day, NPJ & Peacock, SJ 2012, 'Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 106, no. 10, pp. 629-631. https://doi.org/10.1016/j.trstmh.2012.05.007

Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand. / Maude, Rapeephan R.; Vatcharapreechasakul, Teerapon; Ariyaprasert, Pitchayanant et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 106, No. 10, 10.2012, p. 629-631.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand

AU - Maude, Rapeephan R.

AU - Vatcharapreechasakul, Teerapon

AU - Ariyaprasert, Pitchayanant

AU - Maude, Richard J.

AU - Hongsuwan, Maliwan

AU - Yuentrakul, Prayoon

AU - Limmathurotsakul, Direk

AU - Koh, Gavin C.K.W.

AU - Chaowagul, Wipada

AU - Day, Nicholas P.J.

AU - Peacock, Sharon J.

N1 - Funding Information: This study was funded by the Wellcome Trust, London, UK (Grant number 087460/Z/08/Z).

PY - 2012/10

Y1 - 2012/10

N2 - Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).

AB - Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).

KW - Abscess

KW - Burkholderia pseudomallei

KW - Liver

KW - Melioidosis

KW - Spleen

KW - Ultrasound

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DO - 10.1016/j.trstmh.2012.05.007

M3 - Article

C2 - 22770892

AN - SCOPUS:84866001481

SN - 0035-9203

VL - 106

SP - 629

EP - 631

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 10

ER -

Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand

Abstract

Bibliographical note

Keywords

UN SDGs

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