Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand

Rapeephan R. Maude*, Teerapon Vatcharapreechasakul, Pitchayanant Ariyaprasert, Richard J. Maude, Maliwan Hongsuwan, Prayoon Yuentrakul, Direk Limmathurotsakul, Gavin C.K.W. Koh, Wipada Chaowagul, Nicholas P.J. Day, Sharon J. Peacock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).

Original languageEnglish
Pages (from-to)629-631
Number of pages3
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume106
Issue number10
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Bibliographical note

Funding Information:
This study was funded by the Wellcome Trust, London, UK (Grant number 087460/Z/08/Z).

Keywords

  • Abscess
  • Burkholderia pseudomallei
  • Liver
  • Melioidosis
  • Spleen
  • Ultrasound

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