Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Oona Y.C. Lee; Houdini H.T. Wu; Gurdyal S. Besra

doi:10.1016/j.tube.2023.102415

Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Oona Y.C. Lee, Houdini H.T. Wu, Gurdyal S. Besra^*

^*Corresponding author for this work

Birmingham Lab Clinical Development

Research output: Contribution to journal › Review article › peer-review

Abstract

This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

Original language	English
Article number	102415
Journal	Tuberculosis
Volume	143
DOIs	https://doi.org/10.1016/j.tube.2023.102415
Publication status	Published - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

Cell envelope
Cell wall
Lipids
Mycobacterium tuberculosis
Mycolic acids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2023.102415

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title = "Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers",

abstract = "This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.",

keywords = "Cell envelope, Cell wall, Lipids, Mycobacterium tuberculosis, Mycolic acids",

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doi = "10.1016/j.tube.2023.102415",

language = "English",

volume = "143",

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T2 - An era of the mycobacterial cell wall lipid biomarkers

AU - Lee, Oona Y.C.

AU - Wu, Houdini H.T.

AU - Besra, Gurdyal S.

PY - 2023/12

Y1 - 2023/12

N2 - This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

AB - This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

KW - Cell envelope

KW - Cell wall

KW - Lipids

KW - Mycobacterium tuberculosis

KW - Mycolic acids

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DO - 10.1016/j.tube.2023.102415

M3 - Review article

C2 - 38012929

AN - SCOPUS:85178139535

SN - 1472-9792

VL - 143

JO - Tuberculosis

JF - Tuberculosis

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ER -

Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Abstract

Bibliographical note

Keywords

UN SDGs

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