Prevention of perinatal transmission of hepatitis B to babies at high risk: An evaluation

David Sloan, Mary Ramsay*, Leonie Prasad, David Gelb, Chong Gee Teo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We aimed to determine factors associated with successful vaccination coverage and development of infection in high-risk infants born to hepatitis B infected women. Immunisation of 860/932 (92%) of babies was started within 48 h of birth and three doses of vaccination completed for 794/921 (86%). Only 543 (58%) infants were tested and 26 (4.9%) were found to have evidence of current infection. Delayed start of immunisation was significantly associated with unbooked pregnancy, maternal hepatitis B e-markers and year. Current infection in the baby was strongly associated with maternal hepatitis B e-status, ethnicity and year of vaccination. The proportion of infants developing infection declined after 1998, coinciding with the publication of national recommendations and the wider use of the accelerated schedule.

Original languageEnglish
Pages (from-to)5500-5508
Number of pages9
JournalVaccine
Volume23
Issue number48-49
DOIs
Publication statusPublished - 1 Dec 2005

Keywords

  • Evaluation
  • Hepatitis B
  • Immunisation
  • Neonatal
  • Vertical transmission

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