Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: A protocol for a suite of systematic reviews for public health and health systems

Kevin Pottie, Alain D. Mayhew, Rachael L. Morton, Christina Greenaway, Elie A. Akl, Prinon Rahman, Dominik Zenner, Manish Pareek, Peter Tugwell, Vivian Welch, Joerg Meerpohl, Pablo Alonso-Coello, Charles Hui, Beverley Ann Biggs, Ana Requena-Méndez, Eric Agbata, Teymur Noori, Holger J. Schünemann*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)

    Abstract

    Introduction The European Centre for Disease Prevention and Control is developing evidence-based guidance for voluntary screening, treatment and vaccine prevention of infectious diseases for newly arriving migrants to the European Union/European Economic Area. The objective of this systematic review protocol is to guide the identification, appraisal and synthesis of the best available evidence on prevention and assessment of the following priority infectious diseases: tuberculosis, HIV, hepatitis B, hepatitis C, measles, mumps, rubella, diphtheria, tetanus, pertussis, poliomyelitis (polio), Haemophilus influenza disease, strongyloidiasis and schistosomiasis. Methods and analysis The search strategy will identify evidence from existing systematic reviews and then update the effectiveness and cost-effectiveness evidence using prospective trials, economic evaluations and/or recently published systematic reviews. Interdisciplinary teams have designed logic models to help define study inclusion and exclusion criteria, guiding the search strategy and identifying relevant outcomes. We will assess the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Ethics and dissemination There are no ethical or safety issues. We anticipate disseminating the findings through open-access publications, conference abstracts and presentations. We plan to publish technical syntheses as GRADEpro evidence summaries and the systematic reviews as part of a special edition open-access publication on refugee health. We are following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols reporting guideline.

    Original languageEnglish
    Article numbere014608
    JournalBMJ Open
    Volume7
    Issue number9
    DOIs
    Publication statusPublished - 1 Sept 2017

    Bibliographical note

    Funding Information:
    contributors KP, ADM and PR wrote the main text of the protocol. RLM provided content for the methods of cost-effectiveness analysis. CG, EAA, PA-C and CH contributed to the design and research questions. PT, VW, JM, EAA, KP and HJS developed the methods for the project. DZ, MP, B-AB, EA and TN provided substantial content on the research questions and design. All authors read and approved the manuscript. KP is the guarantor. Funding This work is supported by the European Health Group and European Centre for Disease Prevention and Control (ECDC): FWC No ECDC/2015/016, Specific Contract No 1 ECD.5748. The ECDC has suggested experts for review working groups, requested progress reports and provided stakeholder feedback on the proposed protocols. MP is supported by the National Institute for Health Research (NIHR Post-Doctoral Fellowship, MP, PDF-2015-08-102). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.

    Keywords

    • grade
    • infectious disease
    • migrants
    • refugees
    • screening
    • vaccination

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