Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa

N. C. Rollins; M. Dedicoat; S. Danaviah; T. Page; K. Bishop; I. Kleinschmidt; H. M. Coovadia; S. A. Cassol

doi:10.1016/S0140-6736(02)09599-5

Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa

N. C. Rollins, M. Dedicoat, S. Danaviah, T. Page, K. Bishop, I. Kleinschmidt, H. M. Coovadia, S. A. Cassol^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.

Original language	English
Pages (from-to)	389-390
Number of pages	2
Journal	The Lancet
Volume	360
Issue number	9330
DOIs	https://doi.org/10.1016/S0140-6736(02)09599-5
Publication status	Published - 3 Aug 2002
Externally published	Yes

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10.1016/S0140-6736(02)09599-5

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abstract = "Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.",

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AU - Rollins, N. C.

AU - Dedicoat, M.

AU - Danaviah, S.

AU - Page, T.

AU - Bishop, K.

AU - Kleinschmidt, I.

AU - Coovadia, H. M.

AU - Cassol, S. A.

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Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa

Abstract

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