Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

Angeliki Melidou*, Eeva Broberg, Monika Redlberger-Fritz, Therese Popow-Kraupp, Isabelle Thomas, Cyril Barbezange, Nathalie Bossuyt, Helena Jirincova, Alexander Nagy, Ramona Trebbien, Thea K. Fischer, Niina Ikonen, Anu Haveri, Outi Lyytikäinen, Satu Murtopuro, Sylvie Behillil, Vincent Enouf, Sylvie Van Der Werf, Alessandra Falchi, Martine ValetteBruno Lina, Brunhilde Schweiger, Barbara Biere, Susanne Duwe, Marianne Wedde, Silke Buda, Andreas Mentis, Athanasios Kossyvakis, Vasiliki Pogka, Anna Papa-Konidari, Georgia Gioula, Maria Exindari, Linda Dunford, Jeff Connell, Grainne Tuite, Margaret Duffy, Joanne Moran, Bridget Hogg, Allison Waters, Cillian De Gas-Cun, Lisa Domegan, Joan O'Donnell, Michael Joyce, Maria Rita Castrucci, Simona Puzelli, Caterina Rizzo, Anto Nino Bella, Francesco Maraglino, Dinagul Otorbaeva, Gulbarchyn Saparova, Natalija Zamjatina, Gatis Pakarna, Raina Nikiforova, Joël Mossong, Matthias Opp, Adam Meijer, Pieter Overduin, Marit De Lange, Anne Teirlinck, Guus Rim-Melzwaan, Ruud Van Beek, Marion Koopmans, Gé Donker, Olav Hungnes, Karoline Bragstad, Raquel Guiomar, Pedro Pechirra, Paula Cristóvão, Inês Costa, Patricia Conde, Ana Paula Rodrigues, Alina Elena Ivanciuc, Elena Burtseva, Elena Kirillova, Evgeniya Mukasheva, Elena Tichá, Katarina Prosenc, Nataša Berginc, Francisco Pozo, Inmaculada Casas, Amparo Larrauri, Jesús Oliva, Concha Delgado, Raúl Ortiz De Lejarazu Leonardo, Mia Brytting, Åsa Wiman, Samuel Cordey, Ana Rita Goncalves, Damir Perisa, Rita Born, Joanna Ellis, Monica Galiano, Catherine Thompson, Maria Zambon, Richard Pebody, Rory Gunson, Arlene Reynolds, Jim McMenamin, Conall McCaughey, Cathriona Kearns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.

Original languageEnglish
Pages (from-to)4828-4835
Number of pages8
JournalVaccine
Volume35
Issue number37
DOIs
Publication statusPublished - 5 Sep 2017

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • A(H3N2)
  • Amino acid substitution
  • Emergence
  • Europe
  • Influenza virus
  • Season
  • Surveillance

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