Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

Angeliki Melidou; Eeva Broberg; Monika Redlberger-Fritz; Therese Popow-Kraupp; Isabelle Thomas; Cyril Barbezange; Nathalie Bossuyt; Helena Jirincova; Alexander Nagy; Ramona Trebbien; Thea K. Fischer; Niina Ikonen; Anu Haveri; Outi Lyytikäinen; Satu Murtopuro; Sylvie Behillil; Vincent Enouf; Sylvie Van Der Werf; Alessandra Falchi; Martine Valette; Bruno Lina; Brunhilde Schweiger; Barbara Biere; Susanne Duwe; Marianne Wedde; Silke Buda; Andreas Mentis; Athanasios Kossyvakis; Vasiliki Pogka; Anna Papa-Konidari; Georgia Gioula; Maria Exindari; Linda Dunford; Jeff Connell; Grainne Tuite; Margaret Duffy; Joanne Moran; Bridget Hogg; Allison Waters; Cillian De Gas-Cun; Lisa Domegan; Joan O'Donnell; Michael Joyce; Maria Rita Castrucci; Simona Puzelli; Caterina Rizzo; Anto Nino Bella; Francesco Maraglino; Dinagul Otorbaeva; Gulbarchyn Saparova; Natalija Zamjatina; Gatis Pakarna; Raina Nikiforova; Joël Mossong; Matthias Opp; Adam Meijer; Pieter Overduin; Marit De Lange; Anne Teirlinck; Guus Rim-Melzwaan; Ruud Van Beek; Marion Koopmans; Gé Donker; Olav Hungnes; Karoline Bragstad; Raquel Guiomar; Pedro Pechirra; Paula Cristóvão; Inês Costa; Patricia Conde; Ana Paula Rodrigues; Alina Elena Ivanciuc; Elena Burtseva; Elena Kirillova; Evgeniya Mukasheva; Elena Tichá; Katarina Prosenc; Nataša Berginc; Francisco Pozo; Inmaculada Casas; Amparo Larrauri; Jesús Oliva; Concha Delgado; Raúl Ortiz De Lejarazu Leonardo; Mia Brytting; Åsa Wiman; Samuel Cordey; Ana Rita Goncalves; Damir Perisa; Rita Born; Joanna Ellis; Monica Galiano; Catherine Thompson; Maria Zambon; Richard Pebody; Rory Gunson; Arlene Reynolds; Jim McMenamin; Conall McCaughey; Cathriona Kearns

doi:10.1016/j.vaccine.2017.07.057

Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

Angeliki Melidou^*, Eeva Broberg, Monika Redlberger-Fritz, Therese Popow-Kraupp, Isabelle Thomas, Cyril Barbezange, Nathalie Bossuyt, Helena Jirincova, Alexander Nagy, Ramona Trebbien, Thea K. Fischer, Niina Ikonen, Anu Haveri, Outi Lyytikäinen, Satu Murtopuro, Sylvie Behillil, Vincent Enouf, Sylvie Van Der Werf, Alessandra Falchi, Martine ValetteBruno Lina, Brunhilde Schweiger, Barbara Biere, Susanne Duwe, Marianne Wedde, Silke Buda, Andreas Mentis, Athanasios Kossyvakis, Vasiliki Pogka, Anna Papa-Konidari, Georgia Gioula, Maria Exindari, Linda Dunford, Jeff Connell, Grainne Tuite, Margaret Duffy, Joanne Moran, Bridget Hogg, Allison Waters, Cillian De Gas-Cun, Lisa Domegan, Joan O'Donnell, Michael Joyce, Maria Rita Castrucci, Simona Puzelli, Caterina Rizzo, Anto Nino Bella, Francesco Maraglino, Dinagul Otorbaeva, Gulbarchyn Saparova, Natalija Zamjatina, Gatis Pakarna, Raina Nikiforova, Joël Mossong, Matthias Opp, Adam Meijer, Pieter Overduin, Marit De Lange, Anne Teirlinck, Guus Rim-Melzwaan, Ruud Van Beek, Marion Koopmans, Gé Donker, Olav Hungnes, Karoline Bragstad, Raquel Guiomar, Pedro Pechirra, Paula Cristóvão, Inês Costa, Patricia Conde, Ana Paula Rodrigues, Alina Elena Ivanciuc, Elena Burtseva, Elena Kirillova, Evgeniya Mukasheva, Elena Tichá, Katarina Prosenc, Nataša Berginc, Francisco Pozo, Inmaculada Casas, Amparo Larrauri, Jesús Oliva, Concha Delgado, Raúl Ortiz De Lejarazu Leonardo, Mia Brytting, Åsa Wiman, Samuel Cordey, Ana Rita Goncalves, Damir Perisa, Rita Born, Joanna Ellis, Monica Galiano, Catherine Thompson, Maria Zambon, Richard Pebody, Rory Gunson, Arlene Reynolds, Jim McMenamin, Conall McCaughey, Cathriona Kearns

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.

Original language	English
Pages (from-to)	4828-4835
Number of pages	8
Journal	Vaccine
Volume	35
Issue number	37
DOIs	https://doi.org/10.1016/j.vaccine.2017.07.057
Publication status	Published - 5 Sept 2017

Bibliographical note

Publisher Copyright:
© 2017

Keywords

A(H3N2)
Amino acid substitution
Emergence
Europe
Influenza virus
Season
Surveillance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Melidou, A., Broberg, E., Redlberger-Fritz, M., Popow-Kraupp, T., Thomas, I., Barbezange, C., Bossuyt, N., Jirincova, H., Nagy, A., Trebbien, R., Fischer, T. K., Ikonen, N., Haveri, A., Lyytikäinen, O., Murtopuro, S., Behillil, S., Enouf, V., Van Der Werf, S., Falchi, A., ... Kearns, C. (2017). Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18. Vaccine, 35(37), 4828-4835. https://doi.org/10.1016/j.vaccine.2017.07.057

Melidou, Angeliki ; Broberg, Eeva ; Redlberger-Fritz, Monika et al. / Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18. In: Vaccine. 2017 ; Vol. 35, No. 37. pp. 4828-4835.

@article{f920489881e0400faccb91e6b8fadc93,

title = "Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18",

abstract = "During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.",

keywords = "A(H3N2), Amino acid substitution, Emergence, Europe, Influenza virus, Season, Surveillance",

author = "Angeliki Melidou and Eeva Broberg and Monika Redlberger-Fritz and Therese Popow-Kraupp and Isabelle Thomas and Cyril Barbezange and Nathalie Bossuyt and Helena Jirincova and Alexander Nagy and Ramona Trebbien and Fischer, {Thea K.} and Niina Ikonen and Anu Haveri and Outi Lyytik{\"a}inen and Satu Murtopuro and Sylvie Behillil and Vincent Enouf and {Van Der Werf}, Sylvie and Alessandra Falchi and Martine Valette and Bruno Lina and Brunhilde Schweiger and Barbara Biere and Susanne Duwe and Marianne Wedde and Silke Buda and Andreas Mentis and Athanasios Kossyvakis and Vasiliki Pogka and Anna Papa-Konidari and Georgia Gioula and Maria Exindari and Linda Dunford and Jeff Connell and Grainne Tuite and Margaret Duffy and Joanne Moran and Bridget Hogg and Allison Waters and {De Gas-Cun}, Cillian and Lisa Domegan and Joan O'Donnell and Michael Joyce and Castrucci, {Maria Rita} and Simona Puzelli and Caterina Rizzo and Bella, {Anto Nino} and Francesco Maraglino and Dinagul Otorbaeva and Gulbarchyn Saparova and Natalija Zamjatina and Gatis Pakarna and Raina Nikiforova and Jo{\"e}l Mossong and Matthias Opp and Adam Meijer and Pieter Overduin and {De Lange}, Marit and Anne Teirlinck and Guus Rim-Melzwaan and {Van Beek}, Ruud and Marion Koopmans and G{\'e} Donker and Olav Hungnes and Karoline Bragstad and Raquel Guiomar and Pedro Pechirra and Paula Crist{\'o}v{\~a}o and In{\^e}s Costa and Patricia Conde and Rodrigues, {Ana Paula} and Ivanciuc, {Alina Elena} and Elena Burtseva and Elena Kirillova and Evgeniya Mukasheva and Elena Tich{\'a} and Katarina Prosenc and Nata{\v s}a Berginc and Francisco Pozo and Inmaculada Casas and Amparo Larrauri and Jes{\'u}s Oliva and Concha Delgado and {De Lejarazu Leonardo}, {Ra{\'u}l Ortiz} and Mia Brytting and {\AA}sa Wiman and Samuel Cordey and Goncalves, {Ana Rita} and Damir Perisa and Rita Born and Joanna Ellis and Monica Galiano and Catherine Thompson and Maria Zambon and Richard Pebody and Rory Gunson and Arlene Reynolds and Jim McMenamin and Conall McCaughey and Cathriona Kearns",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = sep,

day = "5",

doi = "10.1016/j.vaccine.2017.07.057",

language = "English",

volume = "35",

pages = "4828--4835",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier Ltd.",

number = "37",

}

Melidou, A, Broberg, E, Redlberger-Fritz, M, Popow-Kraupp, T, Thomas, I, Barbezange, C, Bossuyt, N, Jirincova, H, Nagy, A, Trebbien, R, Fischer, TK, Ikonen, N, Haveri, A, Lyytikäinen, O, Murtopuro, S, Behillil, S, Enouf, V, Van Der Werf, S, Falchi, A, Valette, M, Lina, B, Schweiger, B, Biere, B, Duwe, S, Wedde, M, Buda, S, Mentis, A, Kossyvakis, A, Pogka, V, Papa-Konidari, A, Gioula, G, Exindari, M, Dunford, L, Connell, J, Tuite, G, Duffy, M, Moran, J, Hogg, B, Waters, A, De Gas-Cun, C, Domegan, L, O'Donnell, J, Joyce, M, Castrucci, MR, Puzelli, S, Rizzo, C, Bella, AN, Maraglino, F, Otorbaeva, D, Saparova, G, Zamjatina, N, Pakarna, G, Nikiforova, R, Mossong, J, Opp, M, Meijer, A, Overduin, P, De Lange, M, Teirlinck, A, Rim-Melzwaan, G, Van Beek, R, Koopmans, M, Donker, G, Hungnes, O, Bragstad, K, Guiomar, R, Pechirra, P, Cristóvão, P, Costa, I, Conde, P, Rodrigues, AP, Ivanciuc, AE, Burtseva, E, Kirillova, E, Mukasheva, E, Tichá, E, Prosenc, K, Berginc, N, Pozo, F, Casas, I, Larrauri, A, Oliva, J, Delgado, C, De Lejarazu Leonardo, RO, Brytting, M, Wiman, Å, Cordey, S, Goncalves, AR, Perisa, D, Born, R, Ellis, J, Galiano, M, Thompson, C , Zambon, M, Pebody, R, Gunson, R, Reynolds, A, McMenamin, J, McCaughey, C & Kearns, C 2017, 'Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18', Vaccine, vol. 35, no. 37, pp. 4828-4835. https://doi.org/10.1016/j.vaccine.2017.07.057

Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18. / Melidou, Angeliki; Broberg, Eeva; Redlberger-Fritz, Monika et al.
In: Vaccine, Vol. 35, No. 37, 05.09.2017, p. 4828-4835.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

AU - Melidou, Angeliki

AU - Broberg, Eeva

AU - Redlberger-Fritz, Monika

AU - Popow-Kraupp, Therese

AU - Thomas, Isabelle

AU - Barbezange, Cyril

AU - Bossuyt, Nathalie

AU - Jirincova, Helena

AU - Nagy, Alexander

AU - Trebbien, Ramona

AU - Fischer, Thea K.

AU - Ikonen, Niina

AU - Haveri, Anu

AU - Lyytikäinen, Outi

AU - Murtopuro, Satu

AU - Behillil, Sylvie

AU - Enouf, Vincent

AU - Van Der Werf, Sylvie

AU - Falchi, Alessandra

AU - Valette, Martine

AU - Lina, Bruno

AU - Schweiger, Brunhilde

AU - Biere, Barbara

AU - Duwe, Susanne

AU - Wedde, Marianne

AU - Buda, Silke

AU - Mentis, Andreas

AU - Kossyvakis, Athanasios

AU - Pogka, Vasiliki

AU - Papa-Konidari, Anna

AU - Gioula, Georgia

AU - Exindari, Maria

AU - Dunford, Linda

AU - Connell, Jeff

AU - Tuite, Grainne

AU - Duffy, Margaret

AU - Moran, Joanne

AU - Hogg, Bridget

AU - Waters, Allison

AU - De Gas-Cun, Cillian

AU - Domegan, Lisa

AU - O'Donnell, Joan

AU - Joyce, Michael

AU - Castrucci, Maria Rita

AU - Puzelli, Simona

AU - Rizzo, Caterina

AU - Bella, Anto Nino

AU - Maraglino, Francesco

AU - Otorbaeva, Dinagul

AU - Saparova, Gulbarchyn

AU - Zamjatina, Natalija

AU - Pakarna, Gatis

AU - Nikiforova, Raina

AU - Mossong, Joël

AU - Opp, Matthias

AU - Meijer, Adam

AU - Overduin, Pieter

AU - De Lange, Marit

AU - Teirlinck, Anne

AU - Rim-Melzwaan, Guus

AU - Van Beek, Ruud

AU - Koopmans, Marion

AU - Donker, Gé

AU - Hungnes, Olav

AU - Bragstad, Karoline

AU - Guiomar, Raquel

AU - Pechirra, Pedro

AU - Cristóvão, Paula

AU - Costa, Inês

AU - Conde, Patricia

AU - Rodrigues, Ana Paula

AU - Ivanciuc, Alina Elena

AU - Burtseva, Elena

AU - Kirillova, Elena

AU - Mukasheva, Evgeniya

AU - Tichá, Elena

AU - Prosenc, Katarina

AU - Berginc, Nataša

AU - Pozo, Francisco

AU - Casas, Inmaculada

AU - Larrauri, Amparo

AU - Oliva, Jesús

AU - Delgado, Concha

AU - De Lejarazu Leonardo, Raúl Ortiz

AU - Brytting, Mia

AU - Wiman, Åsa

AU - Cordey, Samuel

AU - Goncalves, Ana Rita

AU - Perisa, Damir

AU - Born, Rita

AU - Ellis, Joanna

AU - Galiano, Monica

AU - Thompson, Catherine

AU - Zambon, Maria

AU - Pebody, Richard

AU - Gunson, Rory

AU - Reynolds, Arlene

AU - McMenamin, Jim

AU - McCaughey, Conall

AU - Kearns, Cathriona

PY - 2017/9/5

Y1 - 2017/9/5

N2 - During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.

AB - During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.

KW - A(H3N2)

KW - Amino acid substitution

KW - Emergence

KW - Europe

KW - Influenza virus

KW - Season

KW - Surveillance

UR - http://www.scopus.com/inward/record.url?scp=85028069868&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2017.07.057

DO - 10.1016/j.vaccine.2017.07.057

M3 - Article

C2 - 28780977

AN - SCOPUS:85028069868

SN - 0264-410X

VL - 35

SP - 4828

EP - 4835

JO - Vaccine

JF - Vaccine

IS - 37

ER -

Melidou A, Broberg E, Redlberger-Fritz M, Popow-Kraupp T, Thomas I, Barbezange C et al. Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18. Vaccine. 2017 Sept 5;35(37):4828-4835. doi: 10.1016/j.vaccine.2017.07.057

Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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