Predicting the impact of pneumococcal conjugate vaccine Programme options in Vietnam

Olivier Le Polain De Waroux*, W. John Edmunds, Kensuke Takahashi, Koya Ariyoshi, E. Kim Mulholland, David Goldblatt, Yoon Hong Choi, Dang Duc Anh, Lay Myint Yoshida, Stefan Flasche

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietnam - a country that has not yet introduced PCV - through a dynamic transmission model. We modelled the impact on carriage and invasive pneumococcal disease (IPD) of routine vaccination (RV) only and that of RV with CCs targeting <1y olds (CC1), <2y olds (CC2) and <5y olds (CC5). The model was fitted to nasopharyngeal carriage data, and post-PCV predictions were based on best estimates of parameters governing post-PCV dynamics. With RV only, elimination in carriage of vaccine-type (VT) serotypes is predicted to occur across all age groups within 10 years after introduction, with nearcomplete replacement by non-VT. Most of the benefit of CCs is predicted to occur within the first 3 years with the highest impact at one year, when IPD incidence is predicted to be 11% (95%CrI 9 - 14%) lower than RV with CC1, 25% (21 - 30 %) lower with CC2 and 38% (32 - 46%) lower with CC5. However, CCs would only prevent more cases of IPD insofar as such campaigns do not delay introduction by more than about 6, 12 and 18 months for CC1, CC2 and CC5. Those findings are important to help guide vaccine introduction in countries that have not yet introduced PCV, particularly in Asia.

Original languageEnglish
Pages (from-to)1939-1947
Number of pages9
JournalHuman Vaccines and Immunotherapeutics
Issue number8
Publication statusPublished - 8 Jun 2018

Bibliographical note

Funding Information:
For this work Olivier le Polain was supported by a doctoral research fellowship from the AXA Research Fund. The baseline pneumococcal carriage and population data in Nha Trang was obtained from Nha Trang population based cohort study which was supported by Japan Global Research Network for Infectious Diseases (JGRID). For parts of this work Stefan Flasche was supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 208812/Z/17/Z).

Publisher Copyright:
© 2018 The Author(s).


  • Asia
  • Campaign
  • Catch-up
  • Pneumococcus
  • Vaccine
  • Viet nam


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