Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials

Thomas Lodise; Sam Colman; Daniel S. Stein; David Fitts; Lisa Goldberg; Elizabeth Alexander; Patrick J. Scoble; Jennifer Schranz

doi:10.1093/OFID/OFAA145

Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials

Thomas Lodise^*, Sam Colman, Daniel S. Stein, David Fitts, Lisa Goldberg, Elizabeth Alexander, Patrick J. Scoble, Jennifer Schranz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Time to clinical response, a proxy for hospital "discharge readiness," was compared between CABP inpatients who received lefamulin or moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) trials. The analysis included 926 inpatients. A short and comparable median time to clinical response (4 days) was observed in both treatment groups.

Original language	English
Article number	ofaa145
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	5
DOIs	https://doi.org/10.1093/OFID/OFAA145
Publication status	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Oxford University Press. All rights reserved.

Keywords

Community-acquired bacterial pneumonia
Fluoroquinolones
Lefamulin
Patient discharge
Time to clinical response

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10.1093/OFID/OFAA145

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Lodise, T., Colman, S., Stein, D. S., Fitts, D., Goldberg, L., Alexander, E., Scoble, P. J., & Schranz, J. (2020). Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials. Open Forum Infectious Diseases, 7(5), Article ofaa145. https://doi.org/10.1093/OFID/OFAA145

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abstract = "Time to clinical response, a proxy for hospital {"}discharge readiness,{"} was compared between CABP inpatients who received lefamulin or moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) trials. The analysis included 926 inpatients. A short and comparable median time to clinical response (4 days) was observed in both treatment groups.",

keywords = "Community-acquired bacterial pneumonia, Fluoroquinolones, Lefamulin, Patient discharge, Time to clinical response",

author = "Thomas Lodise and Sam Colman and Stein, {Daniel S.} and David Fitts and Lisa Goldberg and Elizabeth Alexander and Scoble, {Patrick J.} and Jennifer Schranz",

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Lodise, T, Colman, S, Stein, DS, Fitts, D, Goldberg, L, Alexander, E, Scoble, PJ & Schranz, J 2020, 'Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials', Open Forum Infectious Diseases, vol. 7, no. 5, ofaa145. https://doi.org/10.1093/OFID/OFAA145

Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials. / Lodise, Thomas; Colman, Sam; Stein, Daniel S. et al.
In: Open Forum Infectious Diseases, Vol. 7, No. 5, ofaa145, 2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials

AU - Lodise, Thomas

AU - Colman, Sam

AU - Stein, Daniel S.

AU - Fitts, David

AU - Goldberg, Lisa

AU - Alexander, Elizabeth

AU - Scoble, Patrick J.

AU - Schranz, Jennifer

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AB - Time to clinical response, a proxy for hospital "discharge readiness," was compared between CABP inpatients who received lefamulin or moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) trials. The analysis included 926 inpatients. A short and comparable median time to clinical response (4 days) was observed in both treatment groups.

KW - Community-acquired bacterial pneumonia

KW - Fluoroquinolones

KW - Lefamulin

KW - Patient discharge

KW - Time to clinical response

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DO - 10.1093/OFID/OFAA145

M3 - Article

AN - SCOPUS:85085945811

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VL - 7

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

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ER -

Lodise T, Colman S, Stein DS, Fitts D, Goldberg L, Alexander E et al. Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials. Open Forum Infectious Diseases. 2020;7(5):ofaa145. doi: 10.1093/OFID/OFAA145

Post hoc assessment of time to clinical response among adults hospitalized with community- acquired bacterial pneumonia who received either lefamulin or moxifloxacin in 2 phase III randomized, double-blind, double-dummy clinical trials

Abstract

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Keywords

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