TY - JOUR
T1 - Post-exposure prophylaxis of HIV infection in healthcare workers
T2 - Recommendations for the European setting
AU - Puro, Vincenzo
AU - Cicalini, Stefania
AU - De Carli, Gabriella
AU - Soldani, Fabio
AU - Antunes, Francisco
AU - Balslev, Ulla
AU - Begovac, Josip
AU - Bernasconi, Enos
AU - Boaventura, José L.
AU - Martí, Magda Campins
AU - Civljak, Rok
AU - Evans, Barry
AU - Francioli, Patrick
AU - Genasi, Fiona
AU - Larsen, Christine
AU - Lot, Florence
AU - Lunding, Suzanne
AU - Marcus, Ulrich
AU - Pereira, Alvaro A.
AU - Thomas, Tania
AU - Schonwald, Slavko
AU - Ippolito, Giuseppe
N1 - Funding Information:
Protection, Unit F4: Project 2000/SID/107, grant no. SI2.322294. Supported in part by Italian Ministry of Health, AIDS Research ISS grant 30D.66, and Ri-cerca Corrente IRCCS.
Funding Information:
Sources of financial support: European Commission,
PY - 2004/6
Y1 - 2004/6
N2 - The European Commission funded a project for the standardisation of the management of occupational exposures to HIV/blood-borne infections and antiretroviral post-exposure prophylaxis (PEP) in Europe. Within this project, the following recommendations and rationale were formulated by experts representative of participating countries. Based on assessment of the exposure, material, and source characteristics, PEP should be started as soon as possible with any triple combination of antiretrovirals approved for the treatment of HIV-infected patients; initiation is discouraged after 72 hours Rapid HIV testing of the source could reduce inappropriate PEP. HIV testing should be performed at baseline, 4, 12, and 24 weeks, with additional clinical and laboratory monitoring of adverse reactions and potential toxicity at week 1 and 2. HIV resistance tests in the source and direct virus assays in the exposed HCW are not recommended routinely. These easy-to-use recommendations seek to maximise PEP effect while minimising its toxicity and inappropriate use.
AB - The European Commission funded a project for the standardisation of the management of occupational exposures to HIV/blood-borne infections and antiretroviral post-exposure prophylaxis (PEP) in Europe. Within this project, the following recommendations and rationale were formulated by experts representative of participating countries. Based on assessment of the exposure, material, and source characteristics, PEP should be started as soon as possible with any triple combination of antiretrovirals approved for the treatment of HIV-infected patients; initiation is discouraged after 72 hours Rapid HIV testing of the source could reduce inappropriate PEP. HIV testing should be performed at baseline, 4, 12, and 24 weeks, with additional clinical and laboratory monitoring of adverse reactions and potential toxicity at week 1 and 2. HIV resistance tests in the source and direct virus assays in the exposed HCW are not recommended routinely. These easy-to-use recommendations seek to maximise PEP effect while minimising its toxicity and inappropriate use.
KW - Antiretrovirals
KW - HIV
KW - Healthcare workers
KW - Occupational exposure
KW - Post-exposure prophylaxis
UR - http://www.scopus.com/inward/record.url?scp=3442886200&partnerID=8YFLogxK
U2 - 10.1023/B:EJEP.0000032349.57057.8a
DO - 10.1023/B:EJEP.0000032349.57057.8a
M3 - Article
C2 - 15330131
AN - SCOPUS:3442886200
SN - 0393-2990
VL - 19
SP - 577
EP - 584
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 6
ER -
