Post-exposure prophylaxis of HIV infection in healthcare workers: Recommendations for the European setting

Vincenzo Puro*, Stefania Cicalini, Gabriella De Carli, Fabio Soldani, Francisco Antunes, Ulla Balslev, Josip Begovac, Enos Bernasconi, José L. Boaventura, Magda Campins Martí, Rok Civljak, Barry Evans, Patrick Francioli, Fiona Genasi, Christine Larsen, Florence Lot, Suzanne Lunding, Ulrich Marcus, Alvaro A. Pereira, Tania ThomasSlavko Schonwald, Giuseppe Ippolito

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    The European Commission funded a project for the standardisation of the management of occupational exposures to HIV/blood-borne infections and antiretroviral post-exposure prophylaxis (PEP) in Europe. Within this project, the following recommendations and rationale were formulated by experts representative of participating countries. Based on assessment of the exposure, material, and source characteristics, PEP should be started as soon as possible with any triple combination of antiretrovirals approved for the treatment of HIV-infected patients; initiation is discouraged after 72 hours Rapid HIV testing of the source could reduce inappropriate PEP. HIV testing should be performed at baseline, 4, 12, and 24 weeks, with additional clinical and laboratory monitoring of adverse reactions and potential toxicity at week 1 and 2. HIV resistance tests in the source and direct virus assays in the exposed HCW are not recommended routinely. These easy-to-use recommendations seek to maximise PEP effect while minimising its toxicity and inappropriate use.

    Original languageEnglish
    Pages (from-to)577-584
    Number of pages8
    JournalEuropean Journal of Epidemiology
    Issue number6
    Publication statusPublished - Jun 2004

    Bibliographical note

    Funding Information:
    Protection, Unit F4: Project 2000/SID/107, grant no. SI2.322294. Supported in part by Italian Ministry of Health, AIDS Research ISS grant 30D.66, and Ri-cerca Corrente IRCCS.

    Funding Information:
    Sources of financial support: European Commission,


    • Antiretrovirals
    • HIV
    • Healthcare workers
    • Occupational exposure
    • Post-exposure prophylaxis


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