Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A

Gareth Hazell*, Marina Khazova, Howard Cohen, Sarah Felton, Ken Raj

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
16 Downloads (Pure)


Evidence suggests that exposure to UV-A radiation can liberate nitric oxide from skin cells eliciting vasodilation in-vivo. However, the duration of nitric oxide release in skin cells after UV exposure is not well studied, with emphasis on UV-B mediated iNOS upregulation. The current study demonstrated persistence of nitric oxide release in a dark reaction after moderate UV-A exposure, peaking around 48 h post exposure; this effect was shown in keratinocytes, fibroblasts and endothelial cells from neonatal donors and keratinocytes from aged donors and confirmed the hypothesis that UV-A exposure appeared to upregulate cNOS alongside iNOS. Release of nitric oxide in the skin cells induced by a moderate exposure to UV-A in sunlight may be especially beneficial for some demographic groups such as the elderly, hypertensive patients or those with impaired nitric oxide function, not only during exposure but many hours and days after that.

Original languageEnglish
Article number9465
JournalScientific Reports
Issue number1
Publication statusPublished - 8 Jun 2022

Bibliographical note

Funding Information: This study is part funded by the National Institute for Health Research (NIHR) Health Protection Research Unit in Chemical and Radiation Threats and Hazards, a partnership between UK Health Security Agency and Imperial College London. The views expressed are those of the authors and not necessarily those of the NIHR, UKHSA or the Department of Health and Social Care.

This article was funded by National Institute of Health Research (111773).

Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Publisher Copyright: © 2022, Crown.

Citation: Hazell, G., Khazova, M., Cohen, H. et al. Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A. Sci Rep 12, 9465 (2022).



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