Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

P. Hone; Alan Edwards; J. Halls; Roger Cox; D. Lloyd

doi:10.1038/sj.bjc.6601010

Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

P. Hone, Alan Edwards, J. Halls, Roger Cox, D. Lloyd^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).

Original language	English
Pages (from-to)	1939-1941
Number of pages	3
Journal	British Journal of Cancer
Volume	88
Issue number	12
DOIs	https://doi.org/10.1038/sj.bjc.6601010
Publication status	Published - 16 Jun 2003

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Childhood leukaemia
Chromosome aberration
DNA repair
Electromagnetic fields

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abstract = "Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).",

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AU - Hone, P.

AU - Edwards, Alan

AU - Halls, J.

AU - Cox, Roger

AU - Lloyd, D.

PY - 2003/6/16

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N2 - Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).

AB - Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).

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Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

Abstract

Bibliographical note

Keywords

UN SDGs

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