Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023

Elena Ferran; Cathleen Chan; Noorann Sheikh; Martin Dedicoat; Eliza Alexander; Ana Gibertoni-Cruz; James Brown; Esther Robinson; Marc Lipman

doi:10.1093/cid/ciae560

Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023

Elena Ferran
, Cathleen Chan
, Noorann Sheikh
, Martin Dedicoat
, Eliza Alexander
, Ana Gibertoni-Cruz
, James Brown
, Esther Robinson
, Marc Lipman^*

^*Corresponding author for this work

Respiratory Diseases Surveillance TB

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.

Original language	English
Pages (from-to)	660-662
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	80
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciae560
Publication status	Published - 15 Mar 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mycobacterium tuberculosis
drug therapy
fluoroquinolone resistance
whole-genome sequencing

Access to Document

10.1093/cid/ciae560

Cite this

Ferran, E., Chan, C., Sheikh, N., Dedicoat, M., Alexander, E., Gibertoni-Cruz, A., Brown, J., Robinson, E., & Lipman, M. (2025). Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023. Clinical Infectious Diseases, 80(3), 660-662. https://doi.org/10.1093/cid/ciae560

@article{f2cd3826dadc4fe1bed463f992bde331,

title = "Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023",

abstract = "Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4\% overall and 23.9\% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.",

keywords = "Mycobacterium tuberculosis, drug therapy, fluoroquinolone resistance, whole-genome sequencing",

author = "Elena Ferran and Cathleen Chan and Noorann Sheikh and Martin Dedicoat and Eliza Alexander and Ana Gibertoni-Cruz and James Brown and Esther Robinson and Marc Lipman",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2025",

month = mar,

day = "15",

doi = "10.1093/cid/ciae560",

language = "English",

volume = "80",

pages = "660--662",

journal = "Clinical Infectious Diseases",

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}

Ferran, E, Chan, C, Sheikh, N, Dedicoat, M, Alexander, E, Gibertoni-Cruz, A, Brown, J, Robinson, E & Lipman, M 2025, 'Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023', Clinical Infectious Diseases, vol. 80, no. 3, pp. 660-662. https://doi.org/10.1093/cid/ciae560

Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023. / Ferran, Elena; Chan, Cathleen; Sheikh, Noorann et al.
In: Clinical Infectious Diseases, Vol. 80, No. 3, 15.03.2025, p. 660-662.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023

AU - Ferran, Elena

AU - Chan, Cathleen

AU - Sheikh, Noorann

AU - Dedicoat, Martin

AU - Alexander, Eliza

AU - Gibertoni-Cruz, Ana

AU - Brown, James

AU - Robinson, Esther

AU - Lipman, Marc

PY - 2025/3/15

Y1 - 2025/3/15

N2 - Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.

AB - Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.

KW - Mycobacterium tuberculosis

KW - drug therapy

KW - fluoroquinolone resistance

KW - whole-genome sequencing

UR - https://www.scopus.com/pages/publications/105000229203

U2 - 10.1093/cid/ciae560

DO - 10.1093/cid/ciae560

M3 - Article

C2 - 39535753

AN - SCOPUS:105000229203

SN - 1058-4838

VL - 80

SP - 660

EP - 662

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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