Abstract
The relationship of the platelet-mediated autoagglutination of Plasmodium fakiparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n = 63), 41% of severe malaria (n = 104), and 100% of cerebral malaria (n = 15; P = .001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P = .01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.
| Original language | English |
|---|---|
| Pages (from-to) | 1052-1055 |
| Number of pages | 4 |
| Journal | Journal of Infectious Diseases |
| Volume | 189 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 15 Mar 2004 |
| Externally published | Yes |
Bibliographical note
Funding Information:Received 18 July 2003; accepted 11 September 2003; electronically published 27 February 2004. Financial support: Thailand Research Fund; National Institutes of Health (grant A1-01-007); Wellcome Trust–Mahidol University Oxford Tropical Medicine Research Programme. Reprints or correspondence: Prof. Nicholas J. White, 420/6 Rajvithi Rd., Rajvithi, Bangkok 10400, Thailand ([email protected]).
