Placental transfer of ruthenium in rat and guinea-pig

V. M. Levack*, H. Pottinger, John Harrison

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected activity per embryo/foetus on day 12 of gestation to about 0.05% at birth. The relative concentrations of 106 Ru in embryo/foetus and mother (C(f)/C(m) ratio) were about 0.1 in each case. Concentrations in the yolk sac on day 12 were about 1% g-1 compared with 0.01% g-1 in the foetus. Retention in the guinea-pig foetus in late gestation at 7 days after administration (days 50-57) was about 0.2% injected activity per foetus, corresponding to a C(f)/C(m) = 0.2. Retention in each foetoplacental unit was 2% of injected 106Ru with 50% in the yolk sac, 35% in the placenta and 10% in the foetus. For administration 4 weeks prior to conception, the level of 106Ru retained in the foetus on day 57 of gestation was two orders of magnitude lower than after short-term administration, with a C(f)/C(m) about 0.004.

Original languageEnglish
Pages (from-to)809-814
Number of pages6
JournalInternational Journal of Radiation Biology
Volume66
Issue number6
Publication statusPublished - 1994

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