Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions

Alison E. Brown; Robert J. Gifford; Jonathan P. Clewley; Claudia Kucherer; Bernard Masquelier; Kholoud Porter; Claudia Balotta; Nicole K.T. Back; Louise Bruun Jorgensen; Carmen De Mendoza; Krishnan Bhaskaran; O. Noel Gill; Anne M. Johnson; Deenan Pillay

doi:10.1086/596049

Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions

Alison E. Brown, Robert J. Gifford, Jonathan P. Clewley, Claudia Kucherer, Bernard Masquelier, Kholoud Porter, Claudia Balotta, Nicole K.T. Back, Louise Bruun Jorgensen, Carmen De Mendoza, Krishnan Bhaskaran, O. Noel Gill, Anne M. Johnson, Deenan Pillay

HIV & Aids Reporting

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

Original language	English
Pages (from-to)	427-431
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	199
Issue number	3
DOIs	https://doi.org/10.1086/596049
Publication status	Published - 1 Feb 2009

Bibliographical note

Funding Information:
Financial support: University College London Hospitals/University College London Comprehensive Biomedical Centre (support to this study). The CASCADE Collaboration has been funded through the European Union (grants BMH4-CT97–2550, QLK2–2000-01431, QLRT-2001–01708, and LSHP-CT-2006–018949). a Study group members are listed after the text. Reprints or correspondence: Alison Brown, HIV/STI Dept., Health Protection Agency Centre for Infections, 61 Colindale Ave., London NW9 5EQ, UK ([email protected]).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1086/596049

Cite this

Brown, A. E., Gifford, R. J., Clewley, J. P., Kucherer, C., Masquelier, B., Porter, K., Balotta, C., Back, N. K. T., Jorgensen, L. B., De Mendoza, C., Bhaskaran, K., Gill, O. N., Johnson, A. M., & Pillay, D. (2009). Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions. Journal of Infectious Diseases, 199(3), 427-431. https://doi.org/10.1086/596049

@article{ceeb9fa53a5642cb9a7b08481c7795bd,

title = "Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions",

abstract = "Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.",

author = "Brown, {Alison E.} and Gifford, {Robert J.} and Clewley, {Jonathan P.} and Claudia Kucherer and Bernard Masquelier and Kholoud Porter and Claudia Balotta and Back, {Nicole K.T.} and Jorgensen, {Louise Bruun} and {De Mendoza}, Carmen and Krishnan Bhaskaran and Gill, {O. Noel} and Johnson, {Anne M.} and Deenan Pillay",

note = "Funding Information: Financial support: University College London Hospitals/University College London Comprehensive Biomedical Centre (support to this study). The CASCADE Collaboration has been funded through the European Union (grants BMH4-CT97–2550, QLK2–2000-01431, QLRT-2001–01708, and LSHP-CT-2006–018949). a Study group members are listed after the text. Reprints or correspondence: Alison Brown, HIV/STI Dept., Health Protection Agency Centre for Infections, 61 Colindale Ave., London NW9 5EQ, UK ([email protected]).",

year = "2009",

month = feb,

day = "1",

doi = "10.1086/596049",

language = "English",

volume = "199",

pages = "427--431",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

Brown, AE, Gifford, RJ, Clewley, JP, Kucherer, C, Masquelier, B, Porter, K, Balotta, C, Back, NKT, Jorgensen, LB, De Mendoza, C, Bhaskaran, K, Gill, ON, Johnson, AM & Pillay, D 2009, 'Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions', Journal of Infectious Diseases, vol. 199, no. 3, pp. 427-431. https://doi.org/10.1086/596049

TY - JOUR

T1 - Phylogenetic reconstruction of transmission events from individuals with acute HIV infection

T2 - Toward more-rigorous epidemiological definitions

AU - Brown, Alison E.

AU - Gifford, Robert J.

AU - Clewley, Jonathan P.

AU - Kucherer, Claudia

AU - Masquelier, Bernard

AU - Porter, Kholoud

AU - Balotta, Claudia

AU - Back, Nicole K.T.

AU - Jorgensen, Louise Bruun

AU - De Mendoza, Carmen

AU - Bhaskaran, Krishnan

AU - Gill, O. Noel

AU - Johnson, Anne M.

AU - Pillay, Deenan

N1 - Funding Information: Financial support: University College London Hospitals/University College London Comprehensive Biomedical Centre (support to this study). The CASCADE Collaboration has been funded through the European Union (grants BMH4-CT97–2550, QLK2–2000-01431, QLRT-2001–01708, and LSHP-CT-2006–018949). a Study group members are listed after the text. Reprints or correspondence: Alison Brown, HIV/STI Dept., Health Protection Agency Centre for Infections, 61 Colindale Ave., London NW9 5EQ, UK ([email protected]).

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

AB - Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

UR - http://www.scopus.com/inward/record.url?scp=58849137976&partnerID=8YFLogxK

U2 - 10.1086/596049

DO - 10.1086/596049

M3 - Article

C2 - 19133810

AN - SCOPUS:58849137976

SN - 0022-1899

VL - 199

SP - 427

EP - 431

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this