Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: Toward more-rigorous epidemiological definitions

Alison E. Brown, Robert J. Gifford, Jonathan P. Clewley, Claudia Kucherer, Bernard Masquelier, Kholoud Porter, Claudia Balotta, Nicole K.T. Back, Louise Bruun Jorgensen, Carmen De Mendoza, Krishnan Bhaskaran, O. Noel Gill, Anne M. Johnson, Deenan Pillay

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalJournal of Infectious Diseases
Volume199
Issue number3
DOIs
Publication statusPublished - 1 Feb 2009

Bibliographical note

Funding Information:
Financial support: University College London Hospitals/University College London Comprehensive Biomedical Centre (support to this study). The CASCADE Collaboration has been funded through the European Union (grants BMH4-CT97–2550, QLK2–2000-01431, QLRT-2001–01708, and LSHP-CT-2006–018949). a Study group members are listed after the text. Reprints or correspondence: Alison Brown, HIV/STI Dept., Health Protection Agency Centre for Infections, 61 Colindale Ave., London NW9 5EQ, UK (alison.brown@hpa.org.uk).

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