Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

Kira L.F. Hilton; Howard Tolley; Jose L. Ortega-Roldan; Gary S. Thompson; J. Mark Sutton; Charlotte K. Hind; Jennifer R. Hiscock

doi:10.1039/d3cc02320f

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

Kira L.F. Hilton, Howard Tolley, Jose L. Ortega-Roldan, Gary S. Thompson, J. Mark Sutton, Charlotte K. Hind^*, Jennifer R. Hiscock^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.

Original language	English
Pages (from-to)	10504-10507
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	70
DOIs	https://doi.org/10.1039/d3cc02320f
Publication status	Published - 10 Aug 2023

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© 2023 The Royal Society of Chemistry.

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Hilton, K. L. F., Tolley, H., Ortega-Roldan, J. L., Thompson, G. S., Sutton, J. M., Hind, C. K., & Hiscock, J. R. (2023). Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa. Chemical Communications, 59(70), 10504-10507. https://doi.org/10.1039/d3cc02320f

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title = "Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa",

abstract = "We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.",

author = "Hilton, {Kira L.F.} and Howard Tolley and Ortega-Roldan, {Jose L.} and Thompson, {Gary S.} and Sutton, {J. Mark} and Hind, {Charlotte K.} and Hiscock, {Jennifer R.}",

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year = "2023",

month = aug,

day = "10",

doi = "10.1039/d3cc02320f",

language = "English",

volume = "59",

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Hilton, KLF, Tolley, H, Ortega-Roldan, JL, Thompson, GS, Sutton, JM, Hind, CK & Hiscock, JR 2023, 'Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa', Chemical Communications, vol. 59, no. 70, pp. 10504-10507. https://doi.org/10.1039/d3cc02320f

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa. / Hilton, Kira L.F.; Tolley, Howard; Ortega-Roldan, Jose L. et al.
In: Chemical Communications, Vol. 59, No. 70, 10.08.2023, p. 10504-10507.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

AU - Hilton, Kira L.F.

AU - Tolley, Howard

AU - Ortega-Roldan, Jose L.

AU - Thompson, Gary S.

AU - Sutton, J. Mark

AU - Hind, Charlotte K.

AU - Hiscock, Jennifer R.

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AB - We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

IS - 70

ER -

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

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