Phosphoinositides and the Golgi complex

Maria Antonietta De Matteis, Anna Godi, Daniela Corda

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)

Abstract

Phosphoinositides act as precursors of second messengers and membrane ligands for protein modules. Specific lipid kinases and phosphatases are located and differentially regulated in cell organelles, generating a non-uniform distribution of phosphoinositides. Although it is not clear whether and how the phosphoinositide pools are integrated, it is certain that they locally control fundamental processes, including membrane trafficking. This applies to the Golgi complex, where a direct, central role of the phosphatidylinositol 4,5-bisphosphate precursor phosphatidylinositol 4-phosphate has recently been reported.

Original languageEnglish
Pages (from-to)434-447
Number of pages14
JournalCurrent Opinion in Cell Biology
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Aug 2002
Externally publishedYes

Bibliographical note

Funding Information:
The authors would like to thank T Strahl and J Thorner for sharing their unpublished data, CP Berrie for critical reading of the manuscript, R Le Donne for the artwork, and acknowledge the financial support of Telethon Italia (P0203/01, E1290, E841), the Human Frontier Science Programme, the Italian Association for Cancer Research (AIRC), and the European Community (EU grant number HPRN-CT-2000-00081).

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