PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Brunela Pitanga Madureira; Fernanda Marques de Carvalho; Maria Cristina Pessolani; Simon Michael Collin; Patrícia Duarte Deps

doi:10.1016/j.imbio.2019.11.001

PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Brunela Pitanga Madureira
, Fernanda Marques de Carvalho
, Maria Cristina Pessolani
, Simon Michael Collin
, Patrícia Duarte Deps^*

^*Corresponding author for this work

AMR & HCAI Divisional Office

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

Original language	English
Article number	151866
Journal	Immunobiology
Volume	225
Issue number	1
Early online date	10 Nov 2019
DOIs	https://doi.org/10.1016/j.imbio.2019.11.001
Publication status	Published - Jan 2020

Bibliographical note

Funding Information: No specific funding was received for this study.

Open Access: No Open Access licence

Publisher Copyright: © 2019 Elsevier GmbH

Citation: Brunela Pitanga Madureira, Fernanda Marques de Carvalho, Maria Cristina Pessolani, Simon Michael Collin, Patrícia Duarte Deps, PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen’s disease (leprosy) endemic area of Brazil, Immunobiology, Volume 225, Issue 1, 2020, 151866, ISSN 0171-2985.

DOI: https://doi.org/10.1016/j.imbio.2019.11.001.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
LID-1
Leprosy
PGL-1

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10.1016/j.imbio.2019.11.001

Cite this

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title = "PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil",

abstract = "Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 \% (21/350) in HIV-infected compared with 29.1 \% (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 \% (159/350) in HIV-infected compared with 50.3 \% (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.",

keywords = "HIV, LID-1, Leprosy, PGL-1",

author = "Madureira, \{Brunela Pitanga\} and \{de Carvalho\}, \{Fernanda Marques\} and Pessolani, \{Maria Cristina\} and Collin, \{Simon Michael\} and Deps, \{Patr{\'i}cia Duarte\}",

note = "Funding Information: No specific funding was received for this study. Open Access: No Open Access licence Publisher Copyright: {\textcopyright} 2019 Elsevier GmbH Citation: Brunela Pitanga Madureira, Fernanda Marques de Carvalho, Maria Cristina Pessolani, Simon Michael Collin, Patr{\'i}cia Duarte Deps, PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen{\textquoteright}s disease (leprosy) endemic area of Brazil, Immunobiology, Volume 225, Issue 1, 2020, 151866, ISSN 0171-2985. DOI: https://doi.org/10.1016/j.imbio.2019.11.001.",

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AU - de Carvalho, Fernanda Marques

AU - Pessolani, Maria Cristina

AU - Collin, Simon Michael

AU - Deps, Patrícia Duarte

N1 - Funding Information: No specific funding was received for this study. Open Access: No Open Access licence Publisher Copyright: © 2019 Elsevier GmbH Citation: Brunela Pitanga Madureira, Fernanda Marques de Carvalho, Maria Cristina Pessolani, Simon Michael Collin, Patrícia Duarte Deps, PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen’s disease (leprosy) endemic area of Brazil, Immunobiology, Volume 225, Issue 1, 2020, 151866, ISSN 0171-2985. DOI: https://doi.org/10.1016/j.imbio.2019.11.001.

PY - 2020/1

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N2 - Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

AB - Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

KW - HIV

KW - LID-1

KW - Leprosy

KW - PGL-1

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ER -

PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Abstract

Bibliographical note

UN SDGs

Keywords

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