Penetration of efavirenz into the male genital tract: Drug concentrations and antiviral activity in semen and blood of HIV-1-infected men

Stephen Taylor; Helen Reynolds; Caroline A. Sabin; Susan M. Drake; David J. White; David J. Back; Deenan Pillay

doi:10.1097/00002030-200110190-00022

Penetration of efavirenz into the male genital tract: Drug concentrations and antiviral activity in semen and blood of HIV-1-infected men

Stephen Taylor^*, Helen Reynolds, Caroline A. Sabin, Susan M. Drake, David J. White, David J. Back, Deenan Pillay

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor, licensed for the treatment of HIV-1. Data on sanctuary site penetration are limited. Therefore, we measured efavirenz concentrations in the blood and semen of 19 HIV-1-positive men and found concentrations in seminal plasma averaged 10% of those in blood plasma. Furthermore, seminal plasma viral loads were suppressed by 24 weeks of therapy in all patients. These data suggest that efavirenz-containing regimens have antiviral activity within the male genital tract.

Original language	English
Pages (from-to)	2051-2053
Number of pages	3
Journal	AIDS
Volume	15
Issue number	15
DOIs	https://doi.org/10.1097/00002030-200110190-00022
Publication status	Published - 19 Oct 2001
Externally published	Yes

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10.1097/00002030-200110190-00022

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abstract = "Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor, licensed for the treatment of HIV-1. Data on sanctuary site penetration are limited. Therefore, we measured efavirenz concentrations in the blood and semen of 19 HIV-1-positive men and found concentrations in seminal plasma averaged 10% of those in blood plasma. Furthermore, seminal plasma viral loads were suppressed by 24 weeks of therapy in all patients. These data suggest that efavirenz-containing regimens have antiviral activity within the male genital tract.",

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AU - Taylor, Stephen

AU - Reynolds, Helen

AU - Sabin, Caroline A.

AU - Drake, Susan M.

AU - White, David J.

AU - Back, David J.

AU - Pillay, Deenan

PY - 2001/10/19

Y1 - 2001/10/19

N2 - Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor, licensed for the treatment of HIV-1. Data on sanctuary site penetration are limited. Therefore, we measured efavirenz concentrations in the blood and semen of 19 HIV-1-positive men and found concentrations in seminal plasma averaged 10% of those in blood plasma. Furthermore, seminal plasma viral loads were suppressed by 24 weeks of therapy in all patients. These data suggest that efavirenz-containing regimens have antiviral activity within the male genital tract.

AB - Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor, licensed for the treatment of HIV-1. Data on sanctuary site penetration are limited. Therefore, we measured efavirenz concentrations in the blood and semen of 19 HIV-1-positive men and found concentrations in seminal plasma averaged 10% of those in blood plasma. Furthermore, seminal plasma viral loads were suppressed by 24 weeks of therapy in all patients. These data suggest that efavirenz-containing regimens have antiviral activity within the male genital tract.

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JO - AIDS

JF - AIDS

IS - 15

ER -

Penetration of efavirenz into the male genital tract: Drug concentrations and antiviral activity in semen and blood of HIV-1-infected men

Abstract

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