Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice

T. Eoin West*, Nicolle D. Myers, Direk Limmathurotsakul, H. Denny Liggitt, Narisara Chantratita, Sharon J. Peacock, Shawn J. Skerrett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection.

Original languageEnglish
Pages (from-to)1066-1069
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume83
Issue number5
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

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