TY - JOUR
T1 - Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
AU - West, T. Eoin
AU - Myers, Nicolle D.
AU - Limmathurotsakul, Direk
AU - Liggitt, H. Denny
AU - Chantratita, Narisara
AU - Peacock, Sharon J.
AU - Skerrett, Shawn J.
PY - 2010/11
Y1 - 2010/11
N2 - Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection.
AB - Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection.
UR - http://www.scopus.com/inward/record.url?scp=79952054938&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2010.10-0306
DO - 10.4269/ajtmh.2010.10-0306
M3 - Article
C2 - 21036839
AN - SCOPUS:79952054938
SN - 0002-9637
VL - 83
SP - 1066
EP - 1069
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -