Pathbase (http:/www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of mutant or genetically engineered mice and their background strains. The metadata for the images, which allows retrieval and interoperability with other databases, is derived from a series of orthogonal ontologies, and controlled vocabularies. One of these controlled vocabularies, MPATH, was developed by the Pathbase Consortium as a formal description of the content of mouse histopathological images. The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology.
Bibliographical noteFunding Information:
This work was funded by the European Commission under Contract QLRI-CT-1999-00320. The authors would like to thank Drs Cory Brayton, Jerry Ward, Madhuri Warren, Laurence Fiette and Janan Eppig for their invaluable inputs into the development of MPATH and their support of Pathbase.