Passive protection with immunoglobulin A antibodies against tuberculous early infection of the lungs

Ann Williams, Rajko Reljic, Irene Naylor, Simon Clark, Gustavo Falero-Diaz, Mahavir Singh, Stephen Challacombe, Phillip Marsh, Juraj Ivanyi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

119 Citations (Scopus)

Abstract

We report on a new approach toward protection against tuberculosis, based on passive inoculation with immunoglobulin A (IgA) antibodies. In a mouse model of tuberculous lung infection, intranasal inoculations of mice with an IgA monoclonal antibody (mAb) against the α-crystallin antigen of Mycobacterium tuberculosis reduced up to 10-fold the lung bacterial counts at nine days after either aerosol- or intranasal challenge. This effect involved synergism between mAb inoculations shortly before and 3 days after infection. Monomeric IgA reduced the colony-forming unit counts to the same extent as the polymeric IgA, suggesting antibody targeting to Fcα, rather than poly-immunoglobulin receptors on infected lung macrophages. The protective effect was of short duration, presumably due to the rapid degradation of the intranasally applied IgA. Our results provide evidence of an alternative approach which could be further developed toward immunoprophylaxis against tuberculosis in immunocompromised subjects.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalImmunology
Volume111
Issue number3
DOIs
Publication statusPublished - Mar 2004

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